1. A Frontline Clinician's Guide to Managing Opioid-Induced Constipation

3. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the US.

4. Introduction

5. Annual Opioid Prescribing Rates: 2006-2016

6. Opioids Are Associated With Many Common AEs

7. Opioid-Induced Constipation

8. What Is OIC?

9. Pathogenesis of OIC

10. Working Definitions for OIC

11. Assessment and Diagnosis: Tools for Stools

12. Opioid-Related Constipation

13. Overlapping Nature of Constipation

14. Standard Treatment Protocols: Constipation

15. Differentiating OIC From OEC

16. Case 1: 78-Year-Old Maria

17. Case 2: 45-Year-Old Jennifer

18. Bristol Stool Chart

19. BFI

20. Who Is Responsible for Managing OIC?

21. Patient-Provider(s) Partnership for OIC Management

22. Management Strategies

23. Case 1 Reminder: Maria (Aged 78 Years)

24. Case 1: Management for Maria (Aged 78 Years)

25. Commonly Used Laxatives to Treat Constipation

26. Currently Approved Therapies

27. Currently Approved Therapies (cont)

28. Case 2 Reminder: Jennifer (Aged 45 Years)

29. Case 2: Management for Jennifer (Aged 45 Years)

30. Proposed Treatment Algorithm: OEC Based on Responsiveness to Initial Therapy

31. Proposed Real-World Treatment Algorithm: Opioid Constipation-Naive to Therapy

32. Key Messages

33. Abbreviations

34. Abbreviations (cont)