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Radiologic Characteristics of Surgically Resected Non-Small Cell Lung Cancer With ALK Rearrangement or EGFR Mutations  Tae Jung Kim, MD, PhD, Choon-Taek.

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Presentation on theme: "Radiologic Characteristics of Surgically Resected Non-Small Cell Lung Cancer With ALK Rearrangement or EGFR Mutations  Tae Jung Kim, MD, PhD, Choon-Taek."— Presentation transcript:

1 Radiologic Characteristics of Surgically Resected Non-Small Cell Lung Cancer With ALK Rearrangement or EGFR Mutations  Tae Jung Kim, MD, PhD, Choon-Taek Lee, MD, PhD, Sang Hoon Jheon, MD, PhD, Jeong-Soo Park, PhD, Jin-Haeng Chung, MD, PhD  The Annals of Thoracic Surgery  Volume 101, Issue 2, Pages (February 2016) DOI: /j.athoracsur Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Computed tomographic (CT) images of a 45-year-old man with anaplastic lymphoma kinase-positive lung adenocarcinoma. (A) CT scan shows a large solid mass (arrow) with lobulated margin and hypoattenuation with mean attenuation value of 46 Hounsfield units. (B) Lung window image shows ill-defined lesion borders and ground-glass opacity (arrow) at periphery of the tumor. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Computed tomographic (CT) images of a 35-year-old man with anaplastic lymphoma kinase-positive lung adenocarcinoma. CT scan shows a solid mass with lobulated margin (arrowheads) and hypoattenuation with mean attenuation value of 44 Hounsfield units. Multiple mediastinal and hilar lymphadenopathies are also noted (arrow). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Computed tomographic (CT) images of (A and B) adenocarcinoma with epidermal growth factor receptor mutation in a 72-year-old women and (C and D) wild-type/wild-type adenocarcinoma in a 70-year-old man. (A) CT scan shows an irregular mass (arrows) with hyperattenuation with mean attenuation value of 85 Hounsfield units (HU). (B) Lung window image shows a large area of ground-glass opacity (arrowheads) surrounding the solid mass. (C and D) CT images show a solid enhancing nodule (arrow) with mean attenuation value of 75 HU. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Kaplan-Meier curves for overall survival of patients with anaplastic lymphoma kinase (ALK) rearrangement, epidermal growth factor receptor (EGFR) mutation, and wild-type/wild-type (WT/WT) tumors. The median overall survival was significantly longer in ALK-positive patients (37 months) than in patients with EGFR mutation (27 months) and patients with WT/WT tumors (22 months) (p = and p = , respectively). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Graph shows area under the receiver operating characteristic curve (AUC) for discrimination of patients with anaplastic lymphoma kinase rearrangement from those with epidermal growth factor receptor mutation and wild-type/wild-type WT/WT tumor with computed tomographic and clinical findings. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

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