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Regioselective Synthesis of Functionalized Furanones and

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Presentation on theme: "Regioselective Synthesis of Functionalized Furanones and"— Presentation transcript:

1 Regioselective Synthesis of Functionalized Furanones and
Dihydropyranones by Olefin Metathesis Kevin J. Quinn, Department of Chemistry, College of the Holy Cross We have demonstrated the utility of a tandem ring-closing metathesis (RCM)/cross metathesis (CM) strategy for the preparation funtionalized furanones by Implementation in an efficient total synthesis of the antitumor Annonanceous acetogenin squamostolide. We are currently extending this methodology to the preparation of dihydropyranones to be utilized in a total synthesis of the antimalarial agent boronolide.

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