2. Treatment AIMS: Symptomatic: anti-inflammatories Sunbarrier creams
reduce activity
reduce damage
prevent flares
improve quality of life
Symptomatic: anti-inflammatories
Sunbarrier creams
Antimalarials: chloroquine

3. Treatment Corticosteroids: Immunosuppressants:
more severe disease
kidney, serositis, anaemia, cardiac
Immunosuppressants:
azathioprine
Cyclophosphamide
Monitoring and education

4. Prognosis Improved over the last half century Death: earlier diagnosis
better treatment
Death:
SLE
Treatment (sepsis)
Unrelated

5. Prognosis -- deaths SLE related: Overall: Renal Neurological sepsis
vascular

6. Useful antibody tests Antinuclear Factor (ANF) Anti-DNA Antibody (ADA)
Anti-centromere Antibody
Anti-topoisomerase1 Antibody
Extractable Nuclear Antigens Sm
RNP
Ro/ La
Antiphospholipid Antibody(ACLA)

7. Reasons for referral to a Rheumatologist
To confirm a diagnosis
To assess disease activity and severity
To provide a general management plan
To manage uncontrolled disease
To manage life-threatening/ organ disease
To manage/ prevent treatment toxicities
Special circumstances, eg. Pregnancy + APL