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Testing the Amyloid Hypothesis with a Humanized AD Mouse Model

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1 Testing the Amyloid Hypothesis with a Humanized AD Mouse Model
Michelle K. Cahill, Eric J. Huang  Neuron  Volume 93, Issue 5, Pages (March 2017) DOI: /j.neuron Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 A Schematic Diagram Showing the Selective Vulnerability of Human Neurons When Grafted into an Alzheimer’s Disease Mouse Model Although the host mouse neurons and the transplanted human neuron are exposed to Aβ amyloid plaques and to host-derived microglia and astrocytes, the human neurons exhibit more prominent degenerative features, including reduced dendritic density (tan mesh-work), and more dystrophic neurites with accumulation of synaptophysin (SYP)+ and VGlut1+ structures near Aβ amyloid plaques (yellow shaded areas). Furthermore, human neurons show evidence of necrosis, a switch to 4R tau expression, and accumulation of hyperphosphorylated tau (cyan helical structures in cytoplasm). Neuron  , DOI: ( /j.neuron ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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