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Ana Magalhães, Henrique O. Duarte, Celso A. Reis  Cancer Cell 

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Presentation on theme: "Ana Magalhães, Henrique O. Duarte, Celso A. Reis  Cancer Cell "— Presentation transcript:

1 Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis 
Ana Magalhães, Henrique O. Duarte, Celso A. Reis  Cancer Cell  Volume 31, Issue 6, Pages (June 2017) DOI: /j.ccell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Glycosylation Alterations in Cancer
Cancer development and progression encompass major alterations in cell glycosylation, including incomplete synthesis of O-glycan structures, increased expression of branched N-glycans, expression of terminal sialylated glycans, and altered fucosylation. Agrawal et al. identified FUT8-mediated α-1,6 core fucosylation as a molecular driver of metastasis in melanoma by precluding L1CAM protein proteolytic cleavage by plasmin. Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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