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Managing PAD with multiple platelet inhibitors: the effect of combination therapy on bleeding time  Douglas B Wilhite, MD, Anthony J Comerota, MD, Frank.

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Presentation on theme: "Managing PAD with multiple platelet inhibitors: the effect of combination therapy on bleeding time  Douglas B Wilhite, MD, Anthony J Comerota, MD, Frank."— Presentation transcript:

1 Managing PAD with multiple platelet inhibitors: the effect of combination therapy on bleeding time 
Douglas B Wilhite, MD, Anthony J Comerota, MD, Frank A Schmieder, MD, Richard C Throm, BA, John P Gaughan, PhD, A Koneti Rao, MD  Journal of Vascular Surgery  Volume 38, Issue 4, Pages (October 2003) DOI: /S (03)

2 Fig 1 Outline of treatment program. Each treatment phase lasted for 14 days, with an initial washout period, during which the patient took no platelet-inhibiting medications. Washout was repeated throughout the protocol as necessary in order to prevent carryover of drug effects. Journal of Vascular Surgery  , DOI: ( /S (03) )

3 Fig 2 Average bleeding time for each treatment phase. Error bars demonstrate SE. Base, Baseline BT; ASA, aspirin 325 mg QD; Clop, clopidogrel 75 mg QD; Cilo, cilostazol, 100 mg BID. *P ≤ .05 versus baseline. **P ≤ .05 versus all single agents and versus ASA + Cilo and Clop + Cilo. Journal of Vascular Surgery  , DOI: ( /S (03) )

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