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Instructing B Cell Fates on the Fringe

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1 Instructing B Cell Fates on the Fringe
David Allman, Marco Calamito  Immunity  Volume 30, Issue 2, Pages (February 2009) DOI: /j.immuni Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Localization of DL1+ Vascular Endothelial Cells near Incoming Transitional B Cells During peripheral B cell maturation, the least mature transitional B cells (T1 B cells) enter the spleen via the marginal sinus before entering the marginal zone, where they must interact with DL1+ vascular endothelial cells to become marginal zone B cells. The bulk of T1 B cells fail to adequately interact with DL1+ cells and as a result give rise to more mature transitional B cells (T2 B cells), which in turn generate follicular B cells. Elongated cells marked in blue represent DL1+ vascular endothelial cells. Immunity  , DOI: ( /j.immuni ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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