1. Association, recombination and mapping of eukaryotic genes

2. First genetic map of Sturtevant

11. TETRADI ORDINATE

14. Neri-ali norm grigi-ali vest.P
bb/vg+vg b+b+/vgvg
F grigi-ali norm (b+b/vg+vg)
Reincrocio b+b/vg+vg X bb/vgvg
283 grigio, ali norm.
1294 grigio, ali vest.
1418 nero, ali norm.
241 nero, ali vest.

16. X Frequency of recombination= number of recombinants 100
number of the offspring X

17. 1. Verifica concatenzaione attraverso reincrocio
2. Ordine dei geni tramite analisi doppio X-over

19. Frequency of recombination
Distance p-j
SRec I + DRec
Total offspring
X 100%
(52+46) +(4+2)
500
X 100% = 20.8%= 20.8 u.m.
r +
Distance j-r
SRec II x + DRec
Total offspring
X 100%
(22+22) +(4+2)
500
X 100% = 10%= 10 u.m.
Distance p-r
SRec I + SR II + 2x DRec
Total offspring
X 100%
(52+46) +(22+22) +2x(4+2)
500
X 100% = 30.8%

20. Distance between two genes is a map distance (um)
1 um = interval with 1% of recombination
Um = cM centiMorgan

23. MITOTIC CROSSING-OVER (RARE)

28. Mapping by deletion

29. Genetic markers (Molecular genetics)
RFLP (restriction fragment length polymorphism)
VNTR (variable number of tandem repeat)
SNP (single nucleotide polymorphism)