1. Volume 139, Issue 5, Pages 1586-1592.e1 (November 2010)
A Polymorphism Near IL28B Is Associated With Spontaneous Clearance of Acute Hepatitis C Virus and Jaundice 
Hans L. Tillmann, Alex J. Thompson, Keyur Patel, Manfred Wiese, Hannelore Tenckhoff, Hans D. Nischalke, Yuliya Lokhnygina, Ulrike Kullig, Uwe Göbel, Emanuela Capka, Johannes Wiegand, Ingolf Schiefke, Wolfgang Güthoff, Kurt Grüngreiff, Ingrid König, Ulrich Spengler, Jeanette McCarthy, Kevin V. Shianna, David B. Goldstein, John G. McHutchison, Jörg Timm, Jacob Nattermann 
Gastroenterology 
Volume 139, Issue 5, Pages e1 (November 2010)
DOI: /j.gastro
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2. Figure 1
IL28B genotype and spontaneous clearance. IL28B polymorphism shows a strong relationship to spontaneous clearance. The IL28B C/C-type patients had significantly higher rates of viral clearance compared with the T/C and T/T patient types (P < .001). Seven women were exposed but had no positive anti-HCV when tested 10 years after the exposure. Three were C/T, and 4 were C/C. If the 7 women with no clear knowledge on course of infection are excluded, the results are nearly identical (P < .0001), with the exception that the P value for T/T vs C/T is somewhat higher: sided and sided.
Gastroenterology  , e1DOI: ( /j.gastro )
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3. Figure 2
IL28B genotype and clinical presentation at the time of acute infection. A total of 136 patients had information on the acute course of disease. IL28B C/C patients were more likely to be jaundiced and less likely to be asymptomatic. *The numbers in each column indicate the number of patients who cleared the infection and the total number representing each column. ***Comparing the 3 different outcomes of asymptomatic, symptomatic without jaundice, and jaundice in C/C patients versus non-C/C patients was significant at the P = .012 level. Comparing the occurrence of jaundice in the C/C patients versus non-C/C patients was significant at the P = .032 level. Comparing the absence of symptoms in the C/C patients versus non-C/C patients was significant at the P = .007 level.
Gastroenterology  , e1DOI: ( /j.gastro )
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4. Figure 3
Jaundice and spontaneous clearance by IL28B C/C versus non-C/C genotype. Jaundice was related to viral clearance in non-C/C women but not in C/C women. The gray bars indicate the CI. Note that P value is significant for non-C/C patients and the CI for clearance rate does not overlap between jaundice and nonjaundiced women with non-C/C genotype.
Gastroenterology  , e1DOI: ( /j.gastro )
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5. Figure 4
Exploratory analysis of viral clearance in relation to the 3 IL28B genotypes (C/C, C/T, T/T) and the 3 symptom groups (asymptomatic, symptomatic but not jaundiced, and jaundiced). The clearance rate was influenced by jaundice at presentation in the C/T group only.
Gastroenterology  , e1DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions