1. Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs? 
Sarah Anissa Hannou, Kristiaan Wouters, Réjane Paumelle, Bart Staels 
Trends in Endocrinology & Metabolism 
Volume 26, Issue 4, Pages (April 2015)
DOI: /j.tem
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2. Figure 1
Genomic organization of the 9p21.3 locus and its known gene products [p15/cyclin-dependent kinase inhibitor 2B (CDKN2B)–p16/CDKN2A–p14(p19)/alternative reading frame (ARF)–antisense noncoding RNA in the INK4 locus (ANRIL)]. Blue boxes indicate exon locations (approximately to scale). Location of 18 SNPs selected from a 9p21.3 a genome-wide association study (GWAS). Physical positions of the SNPs are based on the National Center for Biotechnology Information (NCBI) database (December 2013; human reference sequence genome assembly GRCh38). Distinct SNPs are associated with cardiovascular disease (CVD) complications like aortic, abdominal (pink) and intracranial aneurysm (brown), coronary artery disease (CAD; green), myocardial infarction (blue), vascular calcification (purple), carotid stenosis (cyan), different cancers [glioma (orange), nasopharyngeal neoplasm (gray), glaucoma (black), and T2D (red)].
Trends in Endocrinology & Metabolism  , DOI: ( /j.tem )
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3. Figure 2
Current understanding of the tissue-specific function of the cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B)–antisense noncoding RNA in the INK4 locus (ANRIL) gene products in the development of cardio-metabolic diseases. By controlling cell proliferation and immune cell phenotypes, CDKN2A/B–ANRIL gene products modulate the development of cardiovascular diseases (CVDs), such as atherosclerosis. Altering immune cell phenotypes influences peripheral and systemic insulin resistance (IR) and may promote metabolic diseases, like type 2 diabetes (T2D). Moreover, the CDKN2A/B–ANRIL gene products control glucose homeostasis also in part by controlling insulin secretion and β cell function, as well as hepatic glucose production. Abbreviations: ATM, adipose tissue macrophage; IR, insulin-resistance; SMC, smooth muscle cell.
Trends in Endocrinology & Metabolism  , DOI: ( /j.tem )
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