1. Influence of nonsteroidal anti-inflammatory drug treatment duration and time of onset on recovery from exercise-induced muscle damage in rats1 
Benoît M Lapointe, PhD, PT, Pierre Frémont, MD, PhD, Claude H Côté, PhD 
Archives of Physical Medicine and Rehabilitation 
Volume 84, Issue 5, Pages (May 2003)
DOI: /S (02)

2. Fig 1
Experimental design used to study the influence of diclofenac sodium treatment duration and time of onset on recovery from exercise-induced muscle damage in rats. Horizontal bars show the time of onset and the duration of diclofenac treatment for each experiment after the protocol of eccentric contractions. Appropriate placebo groups were run in parallel. Asterisks represent the time points of in vitro measurement of tetanic tension.
Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (02) )

3. Fig 2
Influence of diclofenac sodium treatment duration on maximum absolute tetanic tension measured in vitro. The NSAID group received 1mg/kg of diclofenac twice a day by gavage. Tension is expressed as a percentage of the value produced by the sham-operated limb. Values are mean ± standard error (SE) (n=6–8 muscles per group). Letters refer to statistically significant differences between groups (P<.05). Abbreviations: N1,2,3,7, treatment with NSAID for 1, 2, 3, and 7 days; P, placebo; S, sham.
Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (02) )

4. Fig 3
Influence of diclofenac sodium treatment duration on maximum specific tetanic tension. Maximum specific tetanic tension was calculated as previously described. The NSAID group received 1 mg/kg of diclofenac twice a day. Tension is expressed as a percentage of the value produced by the sham-operated limb. Values are mean ± SE (n=6–8 muscles per group). Letters refer to statistically significant differences between groups (P<.05). See fig 2 for abbreviations.
Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (02) )

5. Fig 4
Long-term influence of a 7-day diclofenac sodium treatment on both maximum absolute and specific force production. Tetanic tension was measured in vitro at day 28 postprotocol. Rats received diclofenac sodium (1mg/kg, twice a day) for 7 days. Values are mean ± SE (n=5–7 muscles per group). No significant difference was observed between groups. Abbreviation: Po, tetanic tension.
Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (02) )

6. Fig 5
Influence of a single prophylactic diclofenac sodium dose on both maximum absolute and specific maximum force production. Tetanic tension was measured in vitro 2 days after the eccentric protocol. Rats were given a single dose of diclofenac (1 mg/kg) 45 minutes before the eccentric protocol. Values are mean ± SE (n=4–7 muscles per group). ∗Significantly different from the sham group (P<.05). †Significantly different from the NSAID group (P<.05).
Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (02) )

7. Fig 6
Influence of a delayed treatment with diclofenac sodium on both maximum absolute and specific force production. Tetanic tension was measured in vitro 7 days after the eccentric protocol. Rats received diclofenac (1mg/kg, twice a day) starting 3 days after the eccentric protocol until they were killed. Values are mean ± SE (n=4–7 muscles per group). ∗Significantly different from the sham group (P<.05).
Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (02) )