1. Unmasking Pancreatic Cancer: Epitope Spreading After Single Antigen Chimeric Antigen Receptor T-Cell Therapy in a Human Phase I Trial 
Max Heckler, Stephanie K. Dougan 
Gastroenterology 
Volume 155, Issue 1, Pages (July 2018)
DOI: /j.gastro
Copyright © 2018 AGA Institute Terms and Conditions

2. Figure 1
Epitope spreading. Tumor cell death (1) releases antigens which are phagocytosed by local dendritic cells (DCs) (2). DC activation is enhanced by IFNg and by CD40:CD40L interactions with CARTmeso cells. Activated DCs travel to the draining lymph node (3) where they engage naïve tumor-specific CD8 and CD4 T cells. Activated CD4 T cells may express CD40L and provide help for B cell class switching and antibody production (4). Tumor-specific effector CD4 and CD8 T cells and antibodies are recruited to the tumor microenvironment for perpetuation of a polyfunctional immune response (5).
Gastroenterology  , 11-14DOI: ( /j.gastro )
Copyright © 2018 AGA Institute Terms and Conditions