1. Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans 
Peter Libby, Andrew H. Lichtman, Göran K. Hansson 
Immunity 
Volume 38, Issue 6, Pages (June 2013)
DOI: /j.immuni
Copyright © 2013 Elsevier Inc. Terms and Conditions

2. Figure 1
A Potential Role for Low-Density Lipoprotein as an Antigen that Promotes Atherosclerosis
Native LDL can undergo slight oxidative modification that permits its uptake by PRRs on APCs (which may include DCs) but does not alter amino acid side chains in ApoB sufficiently to interfere with immunogenicity. The ApoB-derived proteins, presented in the context of self MHC, with appropriate costimulation, stimulate proliferation of the antigen-specific T cell clone and aggravation of atherogenesis.
Immunity  , DOI: ( /j.immuni )
Copyright © 2013 Elsevier Inc. Terms and Conditions