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Volume 135, Issue 1, Pages (July 2008)

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1 Volume 135, Issue 1, Pages 61-71 (July 2008)
Survival of Patients Identified as Candidates for Intestinal Transplantation: A 3-Year Prospective Follow-Up  Loris Pironi, Alastair Forbes, Francisca Joly, Virginie Colomb, Malgorzata Lyszkowska, André Van Gossum, Janet Baxter, Paul Thul, Xavier Hébuterne, Manuela Gambarara, Frederic Gottrand, José M. Moreno Villares, Bernard Messing, Olivier Goulet, Michael Staun  Gastroenterology  Volume 135, Issue 1, Pages (July 2008) DOI: /j.gastro Copyright © 2008 AGA Institute Terms and Conditions

2 Figure 1 Study design. A, adults; HPN, home parenteral nutrition; IF, intestinal failure; ITx, intestinal transplantation; P, pediatrics (≤18 years of age). Cause of IF in 72 patients weaned off HPN was short bowel (47 patients; 65.3%), chronic motility disorder (11 patients; 15.3%), intestinal fistula (3 patients; 4.2%), and extensive mucosal disease (11 patients; 15.3%). Gastroenterology  , 61-71DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

3 Figure 2 Kaplan–Meier survival rates of patients (adults and pediatrics) with irreversible intestinal failure on home parenteral nutrition, non-candidates for intestinal transplantation (Noncandidates, n = 320) or candidates for intestinal transplantation who did not undergo a transplantation (Candidates non-Tx, n = 138). Gastroenterology  , 61-71DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

4 Figure 3 Kaplan–Meier survival rates of candidates for intestinal transplantation who did not undergo a transplantation (adults and pediatrics), according to the indication criteria subgroups. Home parenteral nutrition (HPN) failure (n = 69), high risk of death because of the underlying disease (n = 54), high morbidity intestinal failure (IF) or low acceptance of HPN (n = 15). Gastroenterology  , 61-71DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions

5 Figure 4 Kaplan–Meier survival rate in the subgroups of patients who received a small bowel transplant without liver for the first time and of candidates not undergoing transplantation who had a home parenteral nutrition (HPN)–related liver failure or a central venous catheter (CVC)–related major complication. (All the subgroups comprise adult and pediatric patients). First intestinal transplantation (ITx) (n = 10), small bowel transplant without liver transplantation for the first time; HPN liver failure (n = 27), candidates not undergoing transplantation who had HPN-related liver failure; CVC-complications (n = 40), candidates not undergoing transplantation who had multiple CVC-related deep vein thrombosis (n = 33) or frequent sepsis (n = 7). Gastroenterology  , 61-71DOI: ( /j.gastro ) Copyright © 2008 AGA Institute Terms and Conditions


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