1. Part I: A Sensible Approach to Sensitive Troponin

3. Program Goals

4. Case: 46-Year-Old Man Presenting With Stuttering Anterior Chest Discomfort at ED

5. Case: 46-Year-Old Man Presenting With Stuttering Anterior Chest Discomfort at ED (cont)

6. What Is High-Sensitivity Cardiac Troponin Assay?

7. Necrosis Biomarkers Timeline

8. CK-MB and Myoglobin

9. Possible Non-ACS Causes of CTn Elevation

10. High-Sensitivity CTn Distribution in Healthy Reference Population

11. Diagnostic Criteria for AMI[a]

12. Area Under ROC Curve and Time of Symptoms Onset

13. High-Sensitivity CTn Distribution in Healthy Reference Population

14. Analytical Sensitivity vs Clinical Sensitivity

15. More ED Discharges With Increasing Cardiac Troponin Sensitivity

16. Cardiac Troponin During ED Presentation AMI Versus Other Causes

17. Cardiac Troponin Evolution of Temporal Serial Sampling

18. Shrinking Unstable Angina Population

19. Cardiac Troponins

20. TRAPID-AMI Protocol for Early Rule-Out/Rule-In of AMI

21. Implications of Abnormal HS-CTn

22. Quantitative Use of Baseline HS-CTn Levels

23. Acute Heart Failure Mortality According to Time in Hospital and Troponin Status at Presentation

24. Using Recommended Risk Score Cutpoints and Contemporary CTn

25. Using Lower Risk Score Cutpoints With Contemporary CTn

26. More ED Discharges With Increasing Cardiac Troponin Sensitivity

27. Algorithm -- Admit or Discharge

28. Five Keys When Using HS-CTn

29. Case Revisited

30. Follow-Up Programs in Series

31. Abbreviations

32. Abbreviations (cont)