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Volume 143, Issue 6, Pages 1470-1472.e2 (December 2012)
Large Granular Lymphocytic Leukemia: A Treatable Form of Refractory Celiac Disease Georgia Malamut, Bertrand Meresse, Virginie Verkarre, Sophie Kaltenbach, Nicolas Montcuquet, Jean–Paul Duong Van Huyen, Céline Callens, Julien Lenglet, Gabriel Rahmi, Elia Samaha, Brigitte Ranque, Elizabeth Macintyre, Isabelle Radford–Weiss, Olivier Hermine, Nadine Cerf–Bensussan, Christophe Cellier Gastroenterology Volume 143, Issue 6, Pages e2 (December 2012) DOI: /j.gastro Copyright © 2012 AGA Institute Terms and Conditions
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Figure 1 Duodenal biopsy (patient 2). Subtotal villous atrophy in 2010 (A, H&E ×100), glandular apoptotic lesions (B, H&E ×400, arrows). Infiltration by CD8+ (C, ×200), CD3+ (D, ×200), granzyme B+ (E, ×400) lymphocytes. (F) Expression of CD57 on CD8+ T cells freshly isolated from IELs, LPLs, and PBLs. Fluorescence-activated cell sorter analyses were gated on CD45+CD3+ cells. Gastroenterology , e2DOI: ( /j.gastro ) Copyright © 2012 AGA Institute Terms and Conditions
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Figure 2 Duodenal biopsy (patient 2). Normal villi without glandular apoptosis in 2011 (A, HES ×100). Normal number of CD3+ (B, ×100) and CD8+ (C, ×200) IELs and decreased T CD3+, CD8+, and granzyme B+ (D, ×400) LPLs compared with (E) Decrease of LGLs in epithelium and LP, stability in blood. Gastroenterology , e2DOI: ( /j.gastro ) Copyright © 2012 AGA Institute Terms and Conditions
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Supplementary Figure 1 Hepatic biopsy specimen (patient 2). Liver biopsy, performed for mild cytolysis and anicteric cholestasis, showed steatosis with LGLs in hepatic sinusoids CD3+ (A, ×200, arrows) and CD57+ (B, ×400, arrows). Gastroenterology , e2DOI: ( /j.gastro ) Copyright © 2012 AGA Institute Terms and Conditions
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Supplementary Figure 2 Aspect of LGLs in RCDII patient with abnormal circulating cells. Peripheral blood smear showing large lymphocytes with intracytoplasmic granules (arrows). Gastroenterology , e2DOI: ( /j.gastro ) Copyright © 2012 AGA Institute Terms and Conditions
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