1. Figure 2 Outline of the pathogenesis and overlap
of post-infectious malabsorption syndrome (tropical sprue) and post-infectious IBS
Figure 2 | Outline of the pathogenesis and overlap of post-infectious malabsorption syndrome (tropical sprue) and post-infectious IBS. a | Tropical sprue and post-infectious IBS have considerable overlap in terms of pathogenesis, particularly with respect to the involvement of microorganisms. b | Cyclical propagation of small intestinal bacterial overgrowth (SIBO). Intestinal malabsorption of fat reduces gut motility and increases oro-caecal transit time (OCTT) in a mechanism dependent on the ileal brake. Plasma levels of PYY, neurotensin and enteroglucagon are increased in this scenario. Lengthier OCTT in turn promotes bacterial overgrowth.
Ghoshal, U. C. & Gwee, K.-A. (2017) Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link
Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro