1. Digestive System:
Outcome: I can describe different digestive hormones used in the chemical breakdown of food.
Drill:
Which digestive system disorder is the result of blockage of bile and damage to bile duct walls from gallstones?

2. Hormonal Regulation of Digestive Activities
Five major hormones regulate digestive activities
Four of them are produced by the duodenum
Duodenum coordinates gastric activity and digestive secretion according to characteristics of the arriving chyme
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3. Hormonal Regulation of Digestive Activities
Five major hormones regulate digestive activities (continued)
Gastrin
Secreted in pylorus and into duodenum
Stimulated by food presence in stomach and duodenum
Particularly for high protein content
Increases stomach mobility and production of gastric acids and enzymes
Only hormone NOT produced in small intestine (duodenum)
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4. Hormonal Regulation of Digestive Activities
Five major hormones regulate digestive activities (continued)
Secretin
Released by duodenum upon arrival of chyme (food mixed with gastric acids and juices)
Increases secretion of bile from liver and buffers from pancreas (increases pH of chyme)
Also decreases gastric motility and secretory rates
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5. Hormonal Regulation of Digestive Activities
Five major hormones regulate digestive activities (continued)
Gastric inhibitory peptide (GIP)
Released by duodenum when fats and carbohydrates (especially glucose) enter small intestine
Inhibits gastric activity
Increases insulin release from pancreas
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6. Hormonal Regulation of Digestive Activities
Five major hormones regulate digestive activities (continued)
Cholecystokinin (CCK)
Secreted by duodenum when chyme arrives
Especially when chyme contains lipids and partially digested proteins
Increases enzyme production and secretion from pancreas
Causes contraction of the gallbladder
Ejecting bile into the duodenum
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7. Hormonal Regulation of Digestive Activities
Five major hormones regulate digestive activities (continued)
5. Vasoactive intestinal peptide (VIP)
Released by duodenum
Stimulates secretion of intestinal glands
Dilates regional capillaries (to absorb more nutrients)
Inhibits acid production in the stomach
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8. Pattern of hormone release and effects of those hormones in the digestive system
Slide 1
Ingested food
Hormone
Action
Food in
stomach
KEY
Inhibits
Stimulates
Acid production by
parietal cells
Facilitates
Gastrin
Stimulation of gastric
motility; mixing waves
increase in intensity
Release of insulin
from pancreas
GIP
Release of pancreatic
enzymes and buffers
Chyme in
duodenum
Secretin
and CCK
Bile secretion and
ejection of bile from
gallbladder
Dilation of intestinal
capillaries
VIP
Nutrient
absorption
NUTRIENT
UTILIZATION
BY ALL TISSUES
Material
arrives in
jejunum
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Figure 22.14 2

9. You will be assigned one of these hormones: Based on your hormone, create a one-pager with illustrations and images discussing the source of the hormone, its functions, diseases and treatments related to the hormone, and other characteristics (at least 3) about it. This is to be done INDIVIDUALLY
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10. 1: Secretin 2: Cholecystokinin (CCK) 3: Vasoactive Intestinal Peptide (VIP) 4: Gastrin 5: Gastric Inhibitory Peptide (GIP) 6: Pick whichever you want
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11. Digestive System:
Exit Ticket:
Which is the only digestive hormone NOT produced in the small intestine?