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Volume 376, Issue 9746, Pages (September 2010)

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Presentation on theme: "Volume 376, Issue 9746, Pages (September 2010)"— Presentation transcript:

1 Volume 376, Issue 9746, Pages 1074-1084 (September 2010)
10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial  Prof Alison Halliday, FRCS, Prof Michael Harrison, FRCP, Elizabeth Hayter, BMus, Xiangling Kong, MSc, Prof Averil Mansfield, FRCS, Joanna Marro, MSc, Hongchao Pan, PhD, Prof Richard Peto, FRS, Prof John Potter, FRCP, Kazem Rahimi, DM, Angela Rau, MBBS, Steven Robertson, BA, Jonathan Streifler, MD, Prof Dafydd Thomas, FRCP  The Lancet  Volume 376, Issue 9746, Pages (September 2010) DOI: /S (10)61197-X Copyright © 2010 Elsevier Ltd Terms and Conditions

2 Figure 1 Trial profile CEA=carotid endarterectomy. *Not 112, as was reported in 2004. The Lancet  , DOI: ( /S (10)61197-X) Copyright © 2010 Elsevier Ltd Terms and Conditions

3 Figure 2 Allocated and actual use of CEA CEA=carotid endarterectomy.
The Lancet  , DOI: ( /S (10)61197-X) Copyright © 2010 Elsevier Ltd Terms and Conditions

4 Figure 3 10-year risk of any stroke or perioperative death (A) and any non-perioperative stroke (B) After year 10 there were no perioperative strokes and four immediate versus seven deferred first strokes. CEA=carotid endarterectomy. py=per year. The Lancet  , DOI: ( /S (10)61197-X) Copyright © 2010 Elsevier Ltd Terms and Conditions

5 Figure 4 Current use (at or after randomisation) of various medical treatments by year of follow-up and by original treatment allocation (to immediate or deferred CEA) CEA=carotid endarterectomy. DBP=diastolic blood pressure. The Lancet  , DOI: ( /S (10)61197-X) Copyright © 2010 Elsevier Ltd Terms and Conditions

6 Figure 5 10-year risks, by current lipid-lowering therapy (at or after randomisation) CEA=carotid endarterectomy. py=per year. The Lancet  , DOI: ( /S (10)61197-X) Copyright © 2010 Elsevier Ltd Terms and Conditions

7 Figure 6 10-year risks for men and women younger than 75 years of age (mean 66) at entry CEA=carotid endarterectomy. py=per year. The Lancet  , DOI: ( /S (10)61197-X) Copyright © 2010 Elsevier Ltd Terms and Conditions


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