1. Clinical application Dx exercise intolerance 1.1  VO2max   VO2 AT
1.2 RER >1.2 (HRmax is not achieved)
1.3  breathing reserve < 20% (N=20-40%)
1.4  SaO2
1.5 VE/VO2 (ventilatory equivalent for oxygen) > 40
Dx exercise-induced bronchospasm (EIB)
Aerobic fitness evaluation

2. Research study
Optimal level of physical activity in children and adolescent with chronic lung disease

3. Objectives
To study the optimal level of physical activity in children and adolescents with CLD

4. VO2 at AT  correlate with physical activity
Experimental design
Normal (n=18)
CLD (n=18)
Hx & PE
VO2 at AT  correlate with physical activity
PFT
- Spirometry
- Lung volumes
- DLco
Exercise stress test

5. Results Chronic lung diseases: - Chronic interstitial lung 1
- Post lobectomy 5
- Pulmonary hemosiderosis 1
- Fibrotic lung 3
- BPD
- Asthma moderate persistent 6

6. Abnormal PFT Obstructive lung 7 (FEV1 80.0 + 12.9%pred)
Restrictive lung 7 (TLC %pred)
Diffusion defect 1 (DLco/VA = 77 %pred)
Hyperinflation 9 (RV/TLC %pred)

7. CLD
(n = 18)
Control P
FVC
0.002
FEV1
< 0.001
FEV1/FVC
0.047
FEF25-75%
0.001
TLC
0.015
RV/TLC
0.027
DLco/VA
0.671