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Towards Early and More Specific Diagnosis of Prostate Cancer

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Presentation on theme: "Towards Early and More Specific Diagnosis of Prostate Cancer"— Presentation transcript:

1 Towards Early and More Specific Diagnosis of Prostate Cancer
Towards Early and More Specific Diagnosis of Prostate Cancer? Beyond PSA: New Biomarkers Ready for Prime Time  Jack A. Schalken  European Urology Supplements  Volume 8, Issue 3, Pages (January 2009) DOI: /j.eursup Copyright © 2008 European Association of Urology Terms and Conditions

2 Fig. 1 Percentage of men with positive biopsy versus prostate cancer gene 3 score range. The number of men in each group is shown in parentheses. European Urology Supplements 2009 8, DOI: ( /j.eursup ) Copyright © 2008 European Association of Urology Terms and Conditions

3 Fig. 2 Receiver operating characteristic curves for serum prostate-specific antigen (PSA), prostate cancer gene 3 (PCA3) score, and the logistic regression model incorporating serum PSA, PCA3 score, diagnostic digital rectal examination result, and prostate gland volume. PSA=prostate-specific antigen; AUC=area under the curve; PCA3=prostate cancer gene 3; LR=logistic regression; TRUSVol=transrectal ultrasound volume; DRE=digital rectal examination. European Urology Supplements 2009 8, DOI: ( /j.eursup ) Copyright © 2008 European Association of Urology Terms and Conditions

4 Fig. 3 Mean prostate cancer gene 3 scores for men with low-volume/low-grade prostate cancer (<0.5cc, Gleason 6) versus significant prostate cancer (>0.5cc, Gleason ≥7). Error bars represent the standard error of the mean. PCa=prostate cancer. Reprinted from The Journal of Urology, Vol. 179(5), Nakanishi H, Groskopf J, Fritsche HA, et al, PCA3 molecular urine assay correlates with prostate cancer tumor volume: implication in selecting candidates for active surveillance, Pages 1804–10, Copyright (2008), with permission from The American Urological Association. European Urology Supplements 2009 8, DOI: ( /j.eursup ) Copyright © 2008 European Association of Urology Terms and Conditions


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