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A Pilot Study of Fecal Serine-Protease Activity: A Pathophysiologic Factor in Diarrhea- Predominant Irritable Bowel Syndrome  Richárd Róka, András Rosztóczy,

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Presentation on theme: "A Pilot Study of Fecal Serine-Protease Activity: A Pathophysiologic Factor in Diarrhea- Predominant Irritable Bowel Syndrome  Richárd Róka, András Rosztóczy,"— Presentation transcript:

1 A Pilot Study of Fecal Serine-Protease Activity: A Pathophysiologic Factor in Diarrhea- Predominant Irritable Bowel Syndrome  Richárd Róka, András Rosztóczy, Mathilde Leveque, Ferenc Izbéki, Ferenc Nagy, Tamás Molnár, János Lonovics, Rafael Garcia–Villar, Jean Fioramonti, Tibor Wittmann, Lionel Bueno  Clinical Gastroenterology and Hepatology  Volume 5, Issue 5, Pages (May 2007) DOI: /j.cgh Copyright © 2007 AGA Institute Terms and Conditions

2 Figure 1 Fecal serine-protease activity in healthy controls, IBS-C, IBS-A, IBS-D, and UC patients. Boxes extend from the 25th–75th percentiles, lines at the median show the 50th percentile; the whiskers extending above and below the boxes show the highest and lowest values. **P < .001 compared with controls. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

3 Figure 2 Fecal mast cell tryptase activity. See Figure 1 for a description of the groups. Boxes extend from the 25th–75th percentiles, lines at the median show the 50th percentile; the whiskers extending above and below the boxes show the highest and lowest values. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

4 Figure 3 Fecal pancreatic elastase-1 concentration. See Figure 1 for a description of the groups. Boxes extend from the 25th–75th percentiles, lines at the median show the 50th percentile; the whiskers extending above and below the boxes show the highest and lowest values. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions

5 Figure 4 Fecal human SLPI concentration. See Figure 1 for a description of the groups. Boxes extend from the 25th–75th percentiles, lines at the median show the 50th percentile; the whiskers extending above and below the boxes show the highest and lowest values. Clinical Gastroenterology and Hepatology 2007 5, DOI: ( /j.cgh ) Copyright © 2007 AGA Institute Terms and Conditions


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