1. GRB2 SOS1/2 SHC 1/2/3/4 PDGFR PDGF EGFR EGF PKC SPHK 1/2 RAS RAF1
miR-27ab; miR-153; miR-141/200a; miR-124/506; miR-15/16/195/424/497; miR-128; miR-96/1271; miR-182; miR-338/338-3p; miR-150; miR-129/129-5p; miR-17-5p/20/93.mr/106/519.d; miR-203; miR-106/302; miR-183; miR-221/222; miR-22; miR-10; miR-199/199-5p; miR-125/351; miR-138
SOS1/2
SOS1: miR-217; miR-204/211; miR-27ab; miR-124/506; miR-148/152; miR-106/302; miR-128; miR-17-5p/20/93.mr/106/519.d; miR-200bc/429; miR-425/489; miR-181; miR-194; miR-365; miR-9; miR-132/212; miR-203; miR-1/206; miR-24; miR-155; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-15/16/195/424/497; miR-451; miR-103/107; miR-129/129-5p; miR-143; miR-101; miR-18ab; miR-375; miR-96/1271; miR-182; miR-23ab; miR-144; miR-455/455-5p; miR-125/351; miR-223
SOS2: miR-148/152; miR-129/129-5p; miR-130/301; miR-193ab; miR-499/499-5p; miR-199/199-5p; miR-21/590-5p; miR-124/506; miR-19; miR-138; miR-15/16/195/424/497; miR-208/208ab; miR-383; miR-204/211; miR-145; miR-214/761; miR-221/222; miR-96/1271; miR-182; miR-135
SHC
1/2/3/4
SHC1: miR-9; miR-204/211; miR-218; miR-124/506; miR-203; miR-139-5p; miR-18ab; miR-150; miR-200bc/429; miR-219/219-5p; miR-96/1271; miR-153; miR-365; miR-22; miR-216/216b; miR-375; miR-10; miR-7/7ab
SHC2: miR-9; miR-338/338-3p; miR-218; miR-146
SHC3: miR-192/215; miR-338/338-3p
SHC4: miR-129/129-5p; miR-106/302; miR-218; miR-200bc/429; miR-150; miR-182; miR-27ab; miR-203; miR-31; miR-140/140-5p/876-3p; miR-124/506; miR-216/216b; miR-208/208ab; miR-499/499-5p; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-96/1271; miR-101; miR-144; miR-216/216a; miR-128; miR-141/200a; miR-137; miR-155; miR-26ab/1297
PDGFR
PDGF
EGFR
EGF
miR-200bc/429; miR-204/211; miR-135; miR-218; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-182; miR-101; miR-96/1271; miR-1/206; miR-125/351; miR-205; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-214/761; miR-129/129-5p; miR-155; miR-103/107; miR-455/455-5p; miR-223; miR-181
DAG
PKC
SPHK
1/2 *
SPHK1: miR-124/506; miR-1/206
SPHK2: miR-153; miR-130/301; miR-338/338-3p; miR-1/206; miR-19; miR-25/32/92/92ab/363/367; miR-184; miR-137; miR-181; miR-451; miR-503; miR-383; miR-15/16/195/424/497; miR-31
RAS
KRAS: miR-181; miR-27ab; miR-143; miR-217; miR-96/1271; miR-132/212; miR-155; miR-193ab; miR-19; miR-365; miR-199/199-5p; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-141/200a; miR-216/216b; miR-1/206; miR-425/489; miR-129/129-5p; miR-214/761; miR-146; miR-383; miR-190; miR-204/211; miR-23ab; miR-15/16/195/424/497; miR-200bc/429; miR-216/216a; miR-125/351; miR-128; miR-101; miR-218; miR-31; miR-144; miR-7/7ab; miR-194; miR-142-3p; miR-490/490-3p
HRAS: miR-338/338-3p
RAF1
miR-7/7ab; miR-19; miR-15/16/195/424/497; miR-125/351; miR-135; miR-455/455-5p; miR-503; miR-139-5p; miR-150; miR-1/206; miR-143
MAP2K
MAP2K1: miR-181; miR-15/16/195/424/497; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-148/152; miR-144; miR-96/1271; miR-130/301; miR-203; miR-503; miR-139-5p; miR-23ab
MAP2K2: miR-503
MAPK1
miR-204/211; miR-128; miR-132/212; miR-23ab; miR-150; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-27ab; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-190; miR-214/761; miR-10; miR-187; miR-29abc; miR-216/216a; miR-15/16/195/424/497; miR-122; miR-9; miR-125/351
MSK1
miR-130/301; miR-128; miR-148/152; miR-17-5p/20/93.mr/106/519.d; miR-19; miR-27ab; miR-204/211; miR-203; miR-106/302; miR-18ab; miR-103/107; miR-1/206; miR-425/489; miR-144; miR-455/455-5p; miR-199/199-5p; miR-153; miR-129/129-5p; miR-23ab; miR-21/590-5p
RASSF1
miR-181; miR-124/506; miR-96/1271; miR-10; miR-490/490-3p; miR-203; miR-193ab; miR-125/351
DAPK
1/2/3
DAPK1: miR-141/200a; miR-191; miR-26ab/1297; miR-130/301; miR-23ab; miR-143; miR-338/338-3p; miR-124/506; miR-7/7ab; let-7/98; miR-221/222; miR-204/211; miR-383
DAPK2: miR-214/761; miR-129/129-5p; miR-499/499-5p; miR-106/302; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; let-7/98; miR-138; miR-10; miR-17-5p/20/93.mr/106/519.d; miR-25/32/92/92ab/363/367; miR-133; miR-208/208ab; miR-143; miR-122; miR-205
DAPK3: miR-7/7ab; miR-503; miR-128; miR-214/761
miR-7/7ab; miR-27ab; miR-106/302; miR-141/200a; miR-133; miR-155; miR-101; miR-365; miR-455/455-5p; miR-1/206; miR-128; miR-103/107; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-129/129-5p; miR-144; miR-218
miR-499/499-5p; miR-199/199-5p; miR-150; miR-19; miR-145
PDGFA: miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-135; miR-1/206; miR-23ab; miR-196ab; miR-153; miR-221/222; miR-194; miR-141/200a; miR-375
PDGFB: miR-184; miR-17-5p/20/93.mr/106/519.d; let-7/98; miR-143; miR-29abc; miR-122; miR-204/211; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-31; miR-150; miR-139-5p; miR-19
PDGFRA: miR-141/200a; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-17-5p/20/93.mr/106/519.d; miR-146; miR-181; miR-33/33ab; miR-182; miR-219/219-5p; miR-218; miR-128; miR-27ab; miR-24; miR-137; miR-130/301; miR-29abc; miR-455/455-5p; miR-26ab/1297; miR-203; miR-140/140-5p/876-3p; miR-196ab; miR-96/1271; miR-204/211; miR-132/212; miR-375; miR-129/129-5p; miR-143; miR-25/32/92/92ab/363/367; miR-216/216a; miR-193ab; miR-10; miR-139-5p; miR-153; miR-499/499-5p; miR-9; miR-490/490-3p; miR-383; miR-122
PDGFRB: miR-24; miR-9; miR-204/211; miR-338/338-3p; miR-18ab; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-29abc; miR-499/499-5p; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-146; miR-124/506; miR-17-5p/20/93.mr/106/519.d; miR-143; miR-129/129-5p; miR-19; miR-138; miR-365; miR-208/208ab; miR-141/200a; miR-31; miR-181; miR-193ab; miR-223; miR-150; miR-135; miR-122
miR-99ab/100; miR-194; miR-101; miR-145; miR-153; miR-31; miR-18ab; miR-23ab; miR-15/16/195/424/497; miR-22; miR-125/351; miR-503; miR-214/761; miR-24; miR-10; miR-132/212; miR-103/107; miR-29abc; miR-181; miR-19
FGFR3
FGF3
miR-425/489; miR-365; miR-33/33ab; miR-146
PLCG

2. Supplemental Figure 4. Overview of Growth Factor Receptor signaling.
* PRKCA: miR-205; miR-203; miR-199/199-5p; miR-23ab; miR-223; miR-219/219-5p; miR-139-5p; miR-17-5p/20/93.mr/106/519.d; miR-132/212; miR-150; miR-200bc/429;miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-129/129-5p; miR-216/216b; miR-375; miR-15/16/195/424/497; miR-216/216a; miR-22; miR-338/338-3p; miR-141/200a; miR-9; miR-24; miR-183; miR-1/206; miR-193ab; miR-210; miR-125/351; miR-214/761; miR-10; miR-503; miR-181; miR-122; miR-146; miR-138; miR-194; miR-204/211; miR-490/490-3p; miR-192/215; miR-217; miR-7/7ab
PRKCB1: miR-183; miR-129/129-5p; miR-203; miR-141/200a; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-194; miR-182; miR-26ab/1297; miR-106/302; let-7/98; miR-365; miR-184; miR-148/152; miR-33/33ab; miR-29abc; miR-7/7ab
PRKCD: miR-26ab/1297; miR-181; miR-129/129-5p; miR-490/490-3p; miR-218; miR-27ab; miR-15/16/195/424/497
PRKCG: miR-338/338-3p; miR-503; miR-140/140-5p/876-3p; miR-135; miR-1/206
PRKCE: miR-31; miR-96/1271; miR-129/129-5p; miR-216/216a; miR-101; miR-141/200a; miR-146; miR-205; miR-103/107; miR-1/206; miR-33/33ab; miR-182; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-143; miR-223; miR-10; miR-181; miR-383; miR-144; miR-23ab; miR-22; miR-21/590-5p; miR-132/212; miR-218; miR-216/216b; miR-25/32/92/92ab/363/367; miR-139-5p; miR-106/302; miR-125/351; miR-29abc; miR-19
PRKCH: miR-24; miR-205; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-216/216a; miR-204/211; miR-27ab; miR-17-5p/20/93.mr/106/519.d; miR-145; miR-383; miR-216/216b; miR-221/222; miR-200bc/429; miR-455/455-5p; miR-214/761
PRKCI: miR-203; miR-455/455-5p; miR-103/107; miR-219/219-5p; miR-146; miR-365; miR-10; miR-155; miR-183; miR-199/199-5p; miR-23ab; miR-141/200a;miR-204/211;miR-15/16/195/424/497;miR-129/129-5p;miR-24;miR-33/33ab;miR-200bc/429;miR-96/1271;miR-29abc;miR-1/206;miR-150;miR-490/490-3p;miR-217;miR-138;miR-18ab;miR-216/216a;miR-182;miR-181
PRKCQ: miR-26ab/1297; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-192/215; miR-25/32/92/92ab/363/367; miR-203; miR-183; miR-193ab; miR-221/222; miR-137; miR-31; miR-214/761; miR-383; miR-200bc/429
PRKCZ: miR-148/152; miR-15/16/195/424/497; miR-338/338-3p; miR-503
Supplemental Figure 4. Overview of Growth Factor Receptor signaling.
Summary of Growth Factor Receptor signaling and predicted miRNA interactions. miRNAs that were described to be downregulated in bladder cancer are highlighted in green, while upregulated miRNAs are highlighted in red; all other potential interactions are highlighted in black. Target interactions were predicted with TargetScan 5.1. miRNAs presented in this figure are all highly conserved among vertebrates; for a list of other miRNAs see Supplemental Table 5.