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Drug-Induced Liver Injury: Morbidity, Mortality, and Hy’s Law

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1 Drug-Induced Liver Injury: Morbidity, Mortality, and Hy’s Law
Arie Regev  Gastroenterology  Volume 147, Issue 1, Pages (July 2014) DOI: /j.gastro Copyright © Terms and Conditions

2 Figure 1 eDISH, Evaluation of Drug-Induced Serious Hepatotoxicity. eDISH plot showing peak ALT and TBL levels from a database of a phase 3 clinical trial. Over representation of points on study drug in the Hy's Law range quadrant and the Temple's Corollary range quadrant suggests a possible increased risk of severe DILI. ALT, alanine aminotransferase; TBL, total bilirubin; ULRR, upper limit of reference range. Gastroenterology  , 20-24DOI: ( /j.gastro ) Copyright © Terms and Conditions


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