1. IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells
IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells AHuman AEC cultures were stimulated for 4 h with IFNα (circles) or IFNλ (triangles) at specified concentrations and then assessed for stated ISG induction by qPCR (data are representative of 2 independent experiments, n = 3).B, CISG induction in human PBMCs was assessed at 4 and 24 h post‐IFNα (21 U/ml) or IFNλ (1.2 ng/ml) stimulation (B). PBMC proinflammatory cytokine secretion was measured by multiplex cytokine assay at 4 and 24 h post‐stimulation with IFNα or IFNλ (C) (data shown are pooled from six independent donors).Data information: Significance tested by two‐way ANOVA where *denotes IFNα:Veh Ctrl and °indicates IFNα:IFNλ. IFNλ:Veh Ctrl was not significant. IRF7: **P =  Rsad2 4 h: **P = 0.0038, °°P = 0.037; 24 h: *P =  OAS1 4 h: *P = 0.0328, °P = 0.0358; 24 h: ****P <  (B). IL‐6: *P = 0.0124, **P =  MCP‐1 4 h: ****P < 0.0001; °°°P = 0.001; 24 h: **P = 0.0046, °°P =  IP‐10 4 h: **P = 0.0033, °°P = 0.0024; 24 h: **P = 0.0011, °°°P = 0.001 (C). Graphs show mean ± SEM.
Sophia Davidson et al. EMBO Mol Med. 2016;8:
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