Sensory, Motor, and Integrative Systems

Sensory, Motor, and Integrative Systems
Dr. Michael P. Gillespie

Sensation Sensation is the conscious or subconscious awareness of changes in the internal or external environment. Destination of sensory nerve impulses- Spinal cord – reflexes. Lower brain stem – heart rate, breathing rate. Cerebral cortex – we become aware of sensory stimuli. Perception is the conscious awareness and interpretation of sensations (primarily occurs in the cerebral cortex). Dr. Michael P. Gillespie

Sensory Modalities Each unique type of sensation is called a sensory modality. Touch, pain, vision, hearing, etc. A given sensory neuron carries information for only one sensory modality. Two classes of sensory modalities: General senses. Special senses. Dr. Michael P. Gillespie

General Senses General senses refer to both somatic and visceral senses. Somatic senses include tactile sensations (i.e. touch, pressure, vibration, itch, tickle), thermal sensations (warm and cold), pain sensations, and proprioceptive sensations. Proprioceptive sensations monitor static positions and movements. Visceral senses provide information about the organs. Special senses include the sensory modalities of smell, taste, vision, hearing, and equilibrium or balance. Dr. Michael P. Gillespie

Process of Sensation The process of sensation begins in a sensory receptor, which can be either a specialized cell or the dendrites of a sensory neuron. Each sensory receptor responds to a different stimulus. The receptor exhibits selectivity. Dr. Michael P. Gillespie

Sensory Receptor Types

Four Events in Sensation
1. Stimulation of the sensory receptor. Stimulation must occur within the receptive field. 2. Transduction of the stimulus. The receptor transduces (converts) energy in a stimulus into a graded potential. Dr. Michael P. Gillespie

Four Events in Sensation
3. Generation of nerve impulses. When a graded potential reaches threshold, it triggers one or more impulses. Sensory neurons that conduct from PNS to CNS are referred to as first order neurons. 4. Integration of sensory input. Part of the CNS receives and integrates the sensory nerve impulses. Dr. Michael P. Gillespie

Types of Sensory Receptors
Sensory receptors can be classified according to several structural and functional characteristics. 1. Microscopic appearance. Type of potential produced Generator potentials and receptor potentials. 2. Location of receptors and the origin of the stimuli that activate them. 3. According to the type of stimulus they detect. Dr. Michael P. Gillespie

Microscopic Structural Characteristics
Free nerve endings of first-order sensory neurons. Bare dendrites. Pain, thermal, tickle, itch, and some touch sensations. Encapsulated nerve-endings of first-order sensory neurons. Dendrites are enclosed in a connective tissue capsule. Somatic and visceral sensations such as pressure, vibrations, and some touch sensations. i.e. pacinian corpuscles. Dr. Michael P. Gillespie

Microscopic Structural Characteristics
Separate cells that synapse with first-order sensory neurons. i.e. hair cells for hearing and equilibrium, gustatory receptor cells in taste buds, photoreceptors in the retina of the eye, etc. Dr. Michael P. Gillespie

Types of Graded Potentials
Sensory receptors produce two kinds of graded potentials in response to a stimulus. Generator potentials Occur in dendrites of free nerve endings, encapsulated nerve endings, and the receptive part of olfactory receptors. When a generator potential is large enough to reach threshold, it generates an action potential in a first-order neuron. Receptor potentials Occur in sensory receptors that are separate cells. Receptor potentials trigger release of a neurotransmitter through exocytosis of synaptic vesicles. Dr. Michael P. Gillespie

Location of Receptors / Origin of Stimuli
Exteroreceptors Located at or near the external surface of the body. Sensitive to stimuli outside the body. Monitor the external environment. Hearing, vision, smell, taste, touch, pressure, vibration, temperature, and pain. Interoreceptors Located in blood vessels, visceral organs, muscles, and the nervous system. Monitor the internal environment. Usually not consciously perceived; however, strong stimuli may be felt as pain and pressure. Dr. Michael P. Gillespie

Location of Receptors / Origin of Stimuli
Mechanoreceptors Located in muscles, tendons, joints, and the inner ear. Provide information about body position, muscle length and tension, and the position and movement of your joints. There really is no such thing as a proprioceptor. Receptors such as mechanoreceptors participate in proprioceptive pathways. The term proprioceptor is vague and not appropriate; however, its use is ubiquitous in the literature. Dr. Michael P. Gillespie

Type of Stimulus Detected
Most stimuli are in the following forms: Mechanical energy – i.e. sound waves or pressure changes. Electromagnetic energy – i.e. light or heat. Chemical energy – i.e. a molecule of glucose. Dr. Michael P. Gillespie

Mechanoreceptors Sensitive to mechanical stimuli such as the deformation, stretching, or bending of cells. Provide sensations of touch, pressure, vibration, proprioception, hearing, and equilibrium. Thermoreceptors Respond to changes in temperature. Nociceptors Respond to painful stimuli from physical or chemical tissue damage. Dr. Michael P. Gillespie

Photoreceptors Detect light that strikes the retina of the eye. Chemoreceptors Detect chemicals in the mouth (taste), nose (smell), and body fluids. Osmoreceptors Detect the osmotic pressure of body fluids. Baroreceptors Dr. Michael P. Gillespie

Somatic Sensations Somatic sensations arise from stimuli of sensory receptors in the skin or subcutaneous layer; in mucous membranes of the mouth, vagina, and anus; in muscles, tendons, and joints; and in the inner ear. Somatic sensory receptors are distributed unevenly. Highest density – tip of the tongue, lips, fingertips. Cutaneous sensations are those arising from stimulating the surface of the skin. Dr. Michael P. Gillespie

Four Modalities of Somatic Sensation
Tactile Thermal Pain Proprioceptive Dr. Michael P. Gillespie

Tactile Sensations The tactile sensations include touch, pressure, vibration, itch, and tickle. Tactile receptors in the skin or subcutaneous layer include Meissner corpuscles, hair root plexuses, Merkel discs, Ruffini corpuscles, pacinian corpuscles, and free nerve endings. Dr. Michael P. Gillespie

Structure and Location of Sensory Receptors

Touch Sensations of touch arise from stimulation of receptors in the skin and subcutaneous layer. Rapidly adapting touch receptors: Meissner corpuscles Corpuscles of touch. Located in the dermal papillae of hairless skin. Egg shaped mass of dendrites enclosed by a capsule. Hair root plexuses Free nerve endings wrapped around hair follicles. Dr. Michael P. Gillespie

Touch Slowly adapting touch receptors:
Merkel discs (tactile discs or type I cutaneous mechanoreceptors. Saucer shaped, flattened free nerve endings that make contact with Merkel cells. Plentiful in the fingertips, hands, lips, and external genitalia Ruffini corpuscles (type II cutaneous mechanoreceptors). Elongated, encapsulated receptors located deep in the dermis, and in ligaments and tendons. Present in the hands and soles. Sensitive to stretching of digits and limbs. Dr. Michael P. Gillespie

Pressure Pressure is a sustained sensation that is felt over a larger area than touch. It occurs with deformation of deeper tissues. Meissner corpuscles, Merkel discs, and pacinian corpuscles contribute to pressure sensation. Pacinian corpuscles (lamellated corpuscles) are large oval structures composed of a multi-layered connective tissue capsule enclosing a dendrite. Located in the dermis and subcutaneous layer; in submucosal tissues; around joints, tendons, and muscles; in the periosteum; and in the mammary glands, external genitalia, and certain viscera, such as the pancreas and urinary bladder. Dr. Michael P. Gillespie

Vibration Vibration sensation results from rapidly repetitive sensory signals from tactile receptors. Meissner corpuscles and pacinian corpuscles detect vibration. Meissner – lower-frequency vibrations. Pacinian – higher-frequency vibrations. Dr. Michael P. Gillespie

Itch Itch results from stimulation of free nerve endings by certain chemicals, such as bradykinin, often due to a local inflammatory response. Dr. Michael P. Gillespie

Tickle Free nerve endings are thought to mediate the tickle sensation.

Thermal Sensations Thermoreceptors are free nerve endings.
The thermal sensations of coldness and warmth are detected by different receptors. Temperatures below 10⁰ and above 48⁰C primary stimulate pain receptors. Dr. Michael P. Gillespie

Thermal Sensations Cold receptors: Warm receptors:
Located in the stratum basale of the dermis. Attached to medium-diameter type A myelinated fibers. Temperatures between 10⁰ and 40⁰C activate them. Warm receptors: Located in the dermis. Not as abundant as cold receptors. Attached to small-diameter unmyelinated C fibers. Temperatures between 32⁰ and 48⁰C activate them. Dr. Michael P. Gillespie

Phantom Limb Sensation
Patients who have had a limb amputated may still experience sensations such as itching, tingling, or pain as if the limb were still there. This is called phantom limb sensation. Possible causes: Impulses from the proximal portions of sensory neurons that previously carried impulses from the limb. Neurons in the brain that previously received input from the missing limb are still active, giving false sensory perceptions. Dr. Michael P. Gillespie

Phantom Limb Sensation
Treatments such as acupuncture, electrical nerve stimulation, and biofeedback can be helpful in treating phantom limb pain. Dr. Michael P. Gillespie

Pain Sensations Pain serves a protective function by signaling the presence of noxious, tissue-damaging conditions. The subjective description and indication of the location of pain may help identify the underlying disease. The receptors for pain are called nociceptors (noci = harmful). They are free nerve endings found in every tissue of the body except the brain. Dr. Michael P. Gillespie

Pain Sensations Intense thermal, mechanical, or chemical stimuli can activate nociceptors. Tissue irritation or injury releases chemicals such as prostaglandins, kinins, and potassium ions that stimulate nociceptors. Dr. Michael P. Gillespie

Pain Sensations Pain can persist long after the pain-producing stimulus is removed because the pain mediating chemicals linger. Conditions that elicit pain include excessive distention (stretching) of a structure, prolonged muscular contractions, muscle spasms, or ischemia. Dr. Michael P. Gillespie

Types of Pain Types of pain based upon speed of impulses: Fast pain
Medium-diameter, myelinated A fibers. Occurs within 0.1 seconds after a stimulus is applied. Referred to as acute, sharp, or pricking pain. Needle puncture or knife cut to the skin. Not felt in deeper tissues. Dr. Michael P. Gillespie

Types of Pain Slow pain Small-diameter, unmyelinated C fibers.
Begins a second or more after the stimulus is applied. Increases in intensity over several seconds or minutes. Referred to as chronic, burning, or throbbing pain. Can occur in skin, deeper tissues, or internal organs. Dr. Michael P. Gillespie

Types of Pain Types of pain based upon location of pain receptors:
Superficial somatic pain – stimulation of receptors in the skin. Deep somatic pain - stimulation of receptors in skeletal muscles, joints, tendons, and fascia. Visceral pain – stimulation of receptors in visceral organs. Dr. Michael P. Gillespie

Localization of Pain Fast pain Somatic slow pain
Very precisely localized to the stimulated area. i.e. pin prick Somatic slow pain Well localized, but more diffuse Dr. Michael P. Gillespie

Localization of Pain Visceral slow pain
Some is localized to the area of pain Much is referred to the skin that overlies the organ or to a surface area far from the stimulated organ. Know as referred pain. In general, the visceral organ and the area to which the pain is referred are served by the same segment of the spinal cord. Dr. Michael P. Gillespie

Distribution of Referred Pain

Analgesia Analgesia (an = without, algesia = pain) is pain relief.
Types of analgesia: Analgesic drugs such as aspirin and ibuprofen block the formation of prostaglandins, which stimulate nociceptors. Local anesthetics such as novacaine block the conduction of nerve impulses along the axons of first-order pain neurons. Morphine and other opiate drugs alter the quality of pain perception in the brain. Pain is still sensed, but no longer experienced as so noxious. Dr. Michael P. Gillespie

Proprioceptive Sensations
Proprioceptive sensations allow us to know where our head and limbs are located and how they are moving even if we are not looking at them. Kinesthesia (kin = motion, esthesia = perception) is the perception of body movements. Proprioceptive sensations arise in receptors termed mechanoreceptors. Dr. Michael P. Gillespie

Proprioceptive Sensations
Mechanoceptors are embedded in muscles and tendons. These tell us the degree to which the muscle is contracted, the amount of tension on tendons, and the position of joints. Hair receptors in the inner ear monitor the orientation of the head relative to the ground and the head position during movements. The provide information for maintaining balance and equilibrium. Mechanoreceptors also allow for weight discrimination. Dr. Michael P. Gillespie

Mechanoreceptors Three types: Muscle spindles Tendon organs
Located within skeletal muscles Tendon organs Located within tendons Joint kinesthetic receptors Located within synovial joint capsules Dr. Michael P. Gillespie

Muscle Spindles Muscle spindles are located in skeletal muscles.
They consist of several slowly adapting sensory nerve endings that wrap around 3-10 specialized muscle fibers, called intrafusal muscle fibers. Muscle spindles monitor changes in the length of skeletal muscles. The main function of a muscle spindles is to measure muscle length (how much a muscle is being stretched). Dr. Michael P. Gillespie

Muscle Spindles They participate in stretch reflexes.
Activation of the muscle spindle causes contraction of a skeletal muscle, which relieves stretching. They help maintain the level of muscle tone (the small degree of muscle contraction present while the muscle is at rest). Dr. Michael P. Gillespie

Tendon Organs Tendon organs are located at the junction of a tendon and a muscle. They consist of a thin capsule of connective tissue that encloses a few tendon fascicles. The participate in tendon reflexes to protect tendons and their associated muscles from damage due to excessive tension. Tendon reflexes decrease muscle tension by causing muscle relaxation. Dr. Michael P. Gillespie

Muscle Spindles & Tendon Organs

Joint Kinesthetic Receptors
Several types of joint receptors are present within or around the articular capsule of synovial joints. Free nerve endings and Ruffini corpuscles respond to pressure. Pacinian corpuscles respond to acceleration and deceleration of the joint. Articular ligaments contain receptors similar tendon organs that adjust reflex inhibition of adjacent muscles. Dr. Michael P. Gillespie

Somatic Sensory Pathways
Somatic sensory pathways relay information from the somatic sensory receptors to the primary somatosensory area in the cerebral cortex and to the cerebellum. Three sets of neurons First-order neurons Second-order neurons Third-order neurons Dr. Michael P. Gillespie

First-order Neurons Conduct impulses from somatic receptors into the brain stem or spinal cord. Impulses from the face, mouth, teeth, and eyes travel along the cranial nerves. Impulses from the neck, trunk, limbs, and posterior aspect of the head travel along spinal nerves. Dr. Michael P. Gillespie

Second-order Neurons Conduct impulses from the brain stem or spinal cord to the thalamus. The axons decussate in the brain stem or spinal cord before ascending. Consequently, all somatic sensory information from one side of the body reaches the thalamus on the opposite side. Dr. Michael P. Gillespie

Third-order Neurons Conduct impulses from the thalamus to the primary somatosensory cortex on the same side. Dr. Michael P. Gillespie

Relay Stations Regions within the CNS where neurons synapse with other neurons that are part of a particular sensory or motor pathway are known as relay stations. The Thalamus serves as a major relay station. Neural signals are being relayed from one region of the CNS to another. Dr. Michael P. Gillespie

Direct Motor Pathways Dr. Michael P. Gillespie

Somatic sensory impulses ascend to the cerebral cortex via three general pathways. Posterior column-medial lemniscus pathway. Anterolateral (spinothalamic) pathways. Trigeminothalamic pathway. Dr. Michael P. Gillespie

Posterior Column-Medial Lemniscus Pathway
This pathways conveys information for touch, pressure, vibration, and conscious proprioception from the limbs, trunk, neck, and posterior head. Posterior column – in spinal cord. Medial lemniscus – in brain stem. Dr. Michael P. Gillespie

First order neurons from the upper limbs, upper trunk, neck, and posterior head travel in the cuneate fasciculus. First order neurons from the lower limbs and lower trunk travel along the gracile fasciculus. The axons synapse with second order neurons in the cuneate and gracile nuclei respectively. The axons of the second-order neurons decussate in the brain stem and enter the medial lemniscus. Dr. Michael P. Gillespie

The second-order neurons traveling in the medial lemniscus synapse with third-order neurons in the thalamus. Axons from the third order neurons project into the primary somatosensory area of the cortex. Dr. Michael P. Gillespie

Anterolateral Pathway to the Cortex (Spinothalamic)
This pathway conveys information for pain, temperature, itch, and tickle from the limbs, trunk, neck, and posterior head. First order neurons connect to a receptor of the limbs, trunk, neck, or posterior head. Cell bodies are located in the dorsal root ganglion. The first order neurons synapse with second order neurons in the spinal cord. Cell bodies are located in the posterior gray horn of the spinal cord. Dr. Michael P. Gillespie

The axons of the second order neurons decussate and move to the brain stem via the spinothalamic tract. The axons of the second order neurons synapse with third order neurons in the thalamus. The third-order neurons project to the primary somatosensory area of the cortex on the same side as the thalamus. Dr. Michael P. Gillespie

Figure 16.6 Dr. Michael P. Gillespie

Trigeminothalamic Pathway to the Cortex
This pathway conveys information for most somatic sensations from the face, nasal cavity, oral cavity, and teeth. First-order neurons extend from somatic sensory receptors in the face, nasal cavity, oral cavity, and teeth into the pons via the trigeminal nerve. They synapse with second order neurons in the pons. Dr. Michael P. Gillespie

The second order neurons decussate and ascend the trigeminothalamic tract to the thalamus. They synapse with third-order neurons in the thalamus. Dr. Michael P. Gillespie

Figure 16.7 Dr. Michael P. Gillespie

Mapping the Primary Somatosensory Area

Somato-Sensory and Somato-Motor Maps in Cerebral Cortex

Sensory Homunculus Dr. Michael P. Gillespie

Somatic Sensory Pathways to the Cerebellum
The posterior spinocerebellar and anterior spinocerebellar tracts convey nerve impulses from proprioceptors to the cerebellum. This informs the cerebellum of body movements and allows it to coordinate them for smooth, controlled movements. This helps us to maintain posture and balance. Dr. Michael P. Gillespie

Somatic Motor Pathways
Lower motor neurons Have cell bodies in the brain stem and spinal cord. Innervate skeletal muscles Referred to as the final common pathway because only LMNs provide output from the CNS directly to skeletal muscle fibers Upper motor neurons Carry signals form the cerebral cortex to LMNs. Execution of voluntary movements. Maintain balance and coordination. Dr. Michael P. Gillespie

Direct Motor Pathways Lateral corticospinal tract
Anterior corticospinal tract Corticobulbar tract Dr. Michael P. Gillespie

Indirect Motor Pathways
Rubrospinal Tectospinal Vestibulospinal Medial and lateral reticulospinal Dr. Michael P. Gillespie

Lateral Corticospinal Tract (Crossed Pyramidal Tract)
The lateral corticospinal tract provides fine motor control to the limbs and digits. The fibers decussate in the medulla. Dr. Michael P. Gillespie

Anterior Corticospinal Tract (Direct Pyramidal Tract)
The anterior corticospinal tract conducts voluntary motor impulses from the precentral gyrus to the motor centers of the cord. Dr. Michael P. Gillespie

Corticobulbar Tract Connects the cerebral cortex to the brain stem.
“bulbar” refers to the brainstem. Controls the muscles of the face, head, and neck. Innervates the cranial motor nuclei. Dr. Michael P. Gillespie

Rubrospinal Controls large muscle movement such as the arms and legs.
Some fine motor control. Facilitates flexion and inhibits extension in the upper extremities. Dr. Michael P. Gillespie

Tectospinal Coordinates head and eye movements.
Mediates reflex postural movements in response to visual and auditory stimuli. Dr. Michael P. Gillespie

Vestibulospinal The vetsibulospinal tract is a descending tract that originates from the vestibular nuclei of the medulla. The vestibulospinal tract facilitates extensor (antigravity) muscle tone. It assists in maintaining equilibrium. It participates with cranial nerves II, IV, and VI in controlling eye movements. It helps to control head and neck position. Dr. Michael P. Gillespie

Reticulospinal The reticulospinal tract is an extrapyramidal tract which travels from the reticular formation. It has integrative functions that help to coordinate automatic movements of locomotion and posture. Dr. Michael P. Gillespie

Spinal Tracts Dr. Michael P. Gillespie

Referred Pain Distribution

Stages of Sleep Dr. Michael P. Gillespie

Reticular Activating System

Input and Output to Cerebellum

Sensory, Motor, and Integrative Systems

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