1. Polycythemia Vera: A Comprehensive Review and Clinical Recommendations
Ayalew Tefferi, MD 
Mayo Clinic Proceedings 
Volume 78, Issue 2, Pages (February 2003)
DOI: /
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2. Figure 1
Operational classification of the chronic myeloid disorders. ★Atypical chronic myeloid disorders include chronic neutrophilic leukemia, chronic eosinophilic leukemia/hypereosinophilic syndrome, systemic mast cell disease, juvenile myelomonocytic leukemia, chronic myelomonocytic leukemia, and a chronic myeloid process that displays overlapping features of both myelodysplastic syndrome and chronic myeloproliferative disorder. Reprinted with permission from Tefferi.31 Copyright (c)2000 Massachusetts Medical Society. All rights reserved.
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3. Figure 2
The relationship of red blood cell mass and plasma volume in the varieties of poly-cythemias. Hct = hematocrit.
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4. Figure 3
A practical algorithm for the diagnosis of polycythemia vera (PV). Specialized testing includes bone marrow immunohistochemistry for the thrombopoietin receptor (c-mpl), reverse transcriptase-polymerase chain reaction for neutrophil expression of the polycythemia rubra vera-1 gene, and spontaneous erythroid colony assay. ★Note that most PV can be diagnosed by clinical and bone marrow histological parameters and does not require specialized testing. Furthermore, none of the 3 specialized tests can differentiate PV from other myeloproliferative disorders, and their sensitivity and specificity in distinguishing PV from secondary or apparent polycythemia have not been tested rigorously in an adequate number of prospective, well-designed studies that include enough patients to make statistically valid conclusions. A limited number of such studies support the usefulness of these specialized tests in complementing, but not substituting for, other diagnostic procedures.
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5. Figure 4
Serum erythropoietin levels in 42 unselected patients with polycythemia vera. EPO = erythropoietin. Reprinted with permission from Blackwell Publishing.244
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6. Figure 5
Nail pigmentation as a result of treatment with hydroxyurea. Reprinted with permission from Elsevier Science.33
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