1. Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia
by Joan-Lluis Vives Corrons, Estefania Garcia, Joan J. Tusell, Kottayil I. Varughese, Carol West, and Ernest Beutler
Blood
Volume 102(1):
July 1, 2003
©2003 by American Society of Hematology

2. A comparison porcine and human AK
A comparison porcine and human AK. Numbers and asterisks indicate the consecutive sequence of amino acid residues: * (10, 30, 50, etc) and number (20, 40, 60, etc).
A comparison porcine and human AK. Numbers and asterisks indicate the consecutive sequence of amino acid residues: * (10, 30, 50, etc) and number (20, 40, 60, etc). Gray shaded areas indicate the amino acid differences between porcine and human AK.
Joan-Lluis Vives Corrons et al. Blood 2003;102:
©2003 by American Society of Hematology

3. A stereoscopic view of a model for the human AK bound to the substrate AMP. The locations of the 3 mutations, 40, 64, and 140 (141), are indicated in red.
A stereoscopic view of a model for the human AK bound to the substrate AMP. The locations of the 3 mutations, 40, 64, and 140 (141), are indicated in red. The flexible loop containing residue 64 is shown in orange and AMP in blue. The N and C termini are labeled as N and C. The figure was produced using the program BOBSCRIPT.15
Joan-Lluis Vives Corrons et al. Blood 2003;102:
©2003 by American Society of Hematology