1. Analgesic and Sedative Effects of Melatonin in Temporomandibular Disorders: A Double-Blind, Randomized, Parallel-Group, Placebo-Controlled Study 
Liliane Pinto Vidor, DDS, MsH, Iraci L.S. Torres, PharmD, PhD, Izabel Cristina Custódio de Souza, PhD, Felipe Fregni, MD, PhD, Wolnei Caumo, MD, PhD 
Journal of Pain and Symptom Management 
Volume 46, Issue 3, Pages (September 2013)
DOI: /j.jpainsymman
Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

2. Fig. 1
Flow diagram of study, including the number of patients at each study time point. SRQ=Self-Report Questionnaire; RDC/TMD=Research Diagnostic Criteria for Temporomandibular Disorders; VAS=Visual Analogue Scale.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

3. Fig. 2
Mean pain levels (as assessed by VAS) at baseline week (W0), W1, W2, W3, and W4 in the two experimental groups. The error bars indicate standard error of the mean. Asterisks positioned above the bars indicate significant difference (P<0.05) at the time points. Asterisk (*) indicates differences between the placebo and melatonin treatment groups. All comparisons were performed by a mixed analysis of variance model, followed by the Bonferroni test for post hoc multiple comparisons. VAS=Visual Analogue Scale.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

4. Fig. 3
The mean sleep quality from the previous night (as assessed by VASQS) at baseline week (W0), W1, W2, W3, and W4 in the two experimental groups. The error bars indicate standard error of the mean. Asterisks positioned above the bars indicate significant difference (P<0.05) at the various time points. Asterisk (*) indicates the differences between the placebo and melatonin treatment groups. All comparisons were performed using a mixed analysis of variance model, followed by the Bonferroni test for post hoc multiple comparisons. VASQS=Visual Analogue Sleep Quality Scale.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions