Presentation is loading. Please wait.

Presentation is loading. Please wait.

Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug- induced cutaneous eruptions  Nikhil Yawalkar, MD, Maithili Shrikhande,

Published byJudith Dorsey Modified over 6 years ago

Similar presentations

Presentation on theme: "Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug- induced cutaneous eruptions  Nikhil Yawalkar, MD, Maithili Shrikhande,"— Presentation transcript:

1 Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug- induced cutaneous eruptions  Nikhil Yawalkar, MD, Maithili Shrikhande, MD, Yvonne Hari, MD, Helga Nievergelt, MD, Lasse R. Braathen, MD, Werner J. Pichler, MD  Journal of Allergy and Clinical Immunology  Volume 106, Issue 6, Pages (December 2000) DOI: /mai Copyright © 2000 Mosby, Inc. Terms and Conditions

2 Fig. 1 Representative histology of a drug-induced maculopapular exanthem showing a superficial mixed inflammatory cell infiltration with eosinophils (arrows; original magnification 250×). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

3 Fig. 2 Numbers of eosinophils in skin and blood from normal control subjects (n = 9), patients with a drug-induced maculopapular exanthem (n = 9), and patients with psoriasis (n = 8). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

4 Fig. 3 Localization of IL-5, eotaxin, RANTES, MCP-3, and IL-8 immunoreactivity. Representative examples from skin sections from normal skin (a-e) , one patient with a drug-induced maculopapular exanthem (f-j) , and from skin of a patient with psoriasis (k-o) are shown. Arrows indicate positively stained cells (original magnification 250×). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

5 Fig. 4 Quantification of IL-5–, eotaxin-, RANTES-, MCP-3–, and IL-8–positive cells in normal control subjects (n = 9), patients with a drug-induced maculopapular exanthem (n = 9), and patients with psoriasis (n = 8). Mean values ± SEM are shown, and statistical analysis is indicated. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

6 Fig. 5 IL-5 is highly expressed in T lymphocytes in drug-induced maculopapular exanthem. Consecutive skin sections stained with anti-IL-5 (a) and anti-CD3 (b) are shown. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

Download ppt "Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug- induced cutaneous eruptions  Nikhil Yawalkar, MD, Maithili Shrikhande,"

Similar presentations

Daniela P. Metz, PhDa, Annette S

Daniela P. Metz, PhDa, Annette S
Shin-Ichi Nishikawa, MD, PhD 

Shin-Ichi Nishikawa, MD, PhD 
Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses  Chris J. Corrigan, MD, PhD, Wei.

Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses  Chris J. Corrigan, MD, PhD, Wei.
Expression of FcγRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions  Francis Davoine, MSc, Sophie Lavigne, MSc, Jamila.

Expression of FcγRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions  Francis Davoine, MSc, Sophie Lavigne, MSc, Jamila.
The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,
Obstructive sleep apnea syndrome and inflammation

Obstructive sleep apnea syndrome and inflammation
Eosinophil cationic protein and histamine after intestinal challenge in patients with cow's milk intolerance  Ulf Bengtsson, MD, PhDa, Tina W. Knutson,

Eosinophil cationic protein and histamine after intestinal challenge in patients with cow's milk intolerance  Ulf Bengtsson, MD, PhDa, Tina W. Knutson,
Seven cases of complete and incomplete forms of Churg-Strauss syndrome not related to leukotriene receptor antagonists  Androniki Bili, MD, John J. Condemi,

Seven cases of complete and incomplete forms of Churg-Strauss syndrome not related to leukotriene receptor antagonists  Androniki Bili, MD, John J. Condemi,
Road signs guiding leukocytes along the inflammation superhighway

Road signs guiding leukocytes along the inflammation superhighway
Predominance of type 2 cytokine–producing CD4+ and CD8+ cells in patients with atopic dermatitis  Masatoshi Nakazawa, DVMa, Nakako Sugi, MDb, Hiroshi.

Predominance of type 2 cytokine–producing CD4+ and CD8+ cells in patients with atopic dermatitis  Masatoshi Nakazawa, DVMa, Nakako Sugi, MDb, Hiroshi.
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.
Expression of PD-L1 in mastocytosis

Expression of PD-L1 in mastocytosis
Calcitonin gene-related peptide– and vascular endothelial growth factor–positive inflammatory cells in late-phase allergic skin reactions in atopic subjects 

Calcitonin gene-related peptide– and vascular endothelial growth factor–positive inflammatory cells in late-phase allergic skin reactions in atopic subjects 
Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema  Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,
Hong Wei Chu, MDa, Monica Kraft, MDa, James E. Krause, PhDb, Michael D

Hong Wei Chu, MDa, Monica Kraft, MDa, James E. Krause, PhDb, Michael D
Eosinophil extracellular DNA traps in skin diseases

Eosinophil extracellular DNA traps in skin diseases
Youngil I. Koh, MD a, Inseon S

Youngil I. Koh, MD a, Inseon S
Pathophysiology of severe asthma

Pathophysiology of severe asthma
Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses  Chris J. Corrigan, MD, PhD, Wei.

Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses  Chris J. Corrigan, MD, PhD, Wei.
An obligate role for T-cell receptor αβ+ T cells but not T-cell receptor γδ+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis 

An obligate role for T-cell receptor αβ+ T cells but not T-cell receptor γδ+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis 

Similar presentations

Ads by Google