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Breaking Down Neighbors to Fuel Tumorigenesis

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Presentation on theme: "Breaking Down Neighbors to Fuel Tumorigenesis"— Presentation transcript:

1 Breaking Down Neighbors to Fuel Tumorigenesis
John Vaughen, Tatsushi Igaki  Developmental Cell  Volume 40, Issue 3, Pages (February 2017) DOI: /j.devcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Tumors Trigger Non-autonomous Autophagy Both Locally and Systemically (A) Drosophila larvae harboring RasV12, scrib−/− tumors (green) in eye-antennal discs (EAD) undergo systemic autophagy. Tumors can metastasize from brain lobes (BL) and/or EAD into ventral nerve cord (VNC). (B) Local non-autonomous autophagy (NAA) fuels RasV12, scrib−/− growth and metastasis. JNK, Yki, and autocrine JAK-STAT signaling activated by Upd/IL-6 trigger NAA. NAA may contribute to tumor growth by providing nutrients to tumors, including through the amino acid transporter Slimfast. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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