1. Microbiome differences in disease severity and stable or exacerbation visits.
Microbiome differences in disease severity and stable or exacerbation visits. (A) The Shannon Diversity Index and relative abundances of bacteria labelled at the phylum and genus level of samples grouped by COPD disease severity. The bar graphs show the mean relative abundance at the subject level after averaging for multiple measures for that subject. Significant differences in relative abundances between groups are labelled with arrows indicating the relative change in abundance; *P<0.05 (Mann-Whitney). (B) The same alpha diversity and relative abundances grouped by stable or exacerbation status showed fewer differences overall except for Moraxella; *P<0.05 (linear mixed-effects  model). (C) Paired analysis of changes in relative abundances of key genera between matched stable and subsequent exacerbation events; *P<0.05 (paired Student’s t-test).
David Mayhew et al. Thorax doi: /thoraxjnl
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