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Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis  Motohiro Kurosawa, MD,

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Presentation on theme: "Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis  Motohiro Kurosawa, MD,"— Presentation transcript:

1 Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis  Motohiro Kurosawa, MD, PhD, PharmDa, Hiroo Amano, MDa, Naotomo Kanbe, MDa, Sachiko Akimoto, MD, PhDa, Yuko Takeuchia, Tetsuji Yamashita, BSb, Tsutomu Hashimoto, BSb, Fumihiko Kurimoto, BSb, Yoshiki Miyachi, MD, PhDa  Journal of Allergy and Clinical Immunology  Volume 100, Issue 6, Pages S25-S32 (December 1997) DOI: /S (97) Copyright © 1997 Mosby, Inc. Terms and Conditions

2 FIG. 1 Staining patterns of lesional skin (×160 magnification) from an 11-month-old boy with urticaria pigmentosa. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

3 FIG. 1 Staining patterns of lesional skin (×160 magnification) from an 11-month-old boy with urticaria pigmentosa. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

4 FIG. 1 Staining patterns of lesional skin (×160 magnification) from an 11-month-old boy with urticaria pigmentosa. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

5 FIG. 1 Staining patterns of lesional skin (×160 magnification) from an 11-month-old boy with urticaria pigmentosa. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

6 FIG. 2 Staining patterns of gastric mucosa (×160 magnification) from a 41-year-old man with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

7 FIG. 2 Staining patterns of gastric mucosa (×160 magnification) from a 41-year-old man with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

8 FIG. 2 Staining patterns of gastric mucosa (×160 magnification) from a 41-year-old man with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

9 FIG. 2 Staining patterns of gastric mucosa (×160 magnification) from a 41-year-old man with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

10 FIG. 3 Staining patterns of nonlesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

11 FIG. 3 Staining patterns of nonlesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

12 FIG. 3 Staining patterns of nonlesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

13 FIG. 3 Staining patterns of nonlesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

14 FIG. 4 Staining patterns of lesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

15 FIG. 4 Staining patterns of lesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

16 FIG. 4 Staining patterns of lesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

17 FIG. 4 Staining patterns of lesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology  , S25-S32DOI: ( /S (97) ) Copyright © 1997 Mosby, Inc. Terms and Conditions

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