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Strategies for annotation of a genome
Approaches Updating GO annotations
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Approaches for annotation of a genome
Automated approaches 2. Manual approaches a. InterPro2GO a. Sequence similarity b. Experimental evidence
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Annotations via sequence similarity
Alignments published in literature Analysis using full length protein
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Annotation from experimental evidence
Focus on known genes Identify literature relevant to that gene a. using gene names, species name Complete annotation set for a gene Annotate all available experimental data “unknown” annotations ok
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Updating GO annotations
GO annotations will never be “done” Ongoing process New experimental data More specific annotation Replace obsolete terms
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