1. In Utero Depletion Of Fetal Host Hematopoietic Stem Cells Improves Engraftment Following Neonatal Transplantation In Mice
by Chris Derderian, Charmin King, Priya Togarrati, Agnieszka Czechowicz, Ninnia Lescano, Damien Reynaud, Emmanuelle Passegue, Irving L Weissman, and Tippi MacKenzie
Blood
Volume 122(21):
November 15, 2013
©2013 by American Society of Hematology

2. (A) Absolute number of KLS cells in long bones of animals treated with ACK2 or control on E14.5 and harvested on P1. * p<0.001, n=5-18/group.
(A) Absolute number of KLS cells in long bones of animals treated with ACK2 or control on E14.5 and harvested on P1. * p<0.001, n=5-18/group. (B) Levels of donor peripheral blood CD45 cell chimerism in treated animals after in utero ACK2 treatment and neonatal transplantation, or in utero transplantation alone. * p<0.05 between control and all doses, n≥4/group, * * p<0.05 between 2.5 µg or 5 µg and in utero transplant at 12 weeks, n≥4/group.
Charmin King et al. Blood 2013;122:3240
©2013 by American Society of Hematology