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Using biomarkers to predict the presence of FAS mutations in patients with features of the autoimmune lymphoproliferative syndrome  Iusta Caminha, MD,

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Presentation on theme: "Using biomarkers to predict the presence of FAS mutations in patients with features of the autoimmune lymphoproliferative syndrome  Iusta Caminha, MD,"— Presentation transcript:

1 Using biomarkers to predict the presence of FAS mutations in patients with features of the autoimmune lymphoproliferative syndrome  Iusta Caminha, MD, Thomas A. Fleisher, MD, Ronald L. Hornung, PhD, Janet K. Dale, RN, MPH, Julie E. Niemela, MLS (ASCP), Susan Price, RN, Joie Davis, CRNP, Katie Perkins, CRNP, Kennichi C. Dowdell, PhD, Margaret R. Brown, MLS (ASCP), V. Koneti Rao, MD, João Bosco Oliveira, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 125, Issue 4, Pages e6 (April 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Biomarkers in patients with ALPS and control groups. Dashed lines represent cut-off values used to calculate likelihood ratios. Bars denote median values. P values for the differences between groups were obtained by Mann-Whitney test and are shown above each graph (∗∗∗P < .0001; ∗∗P < .001; ∗P < .05; NS, no significant difference). HMPR, Healthy mutation-positive relative; MNR, mutation negative relative. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 sFASL levels and combinations of biomarkers accurately predict FAS mutations. A, Scatter plot showing sFASL levels. Increasing (B) and decreasing (C) probabilities for having a FAS mutation according to the percentage of αβ-DNT cells, levels of vitamin B12, IL-10, IL-18, sFASL, and results of FAS-induced apoptosis assay. Bars denote median values. P values for the differences between groups were obtained by Mann-Whitney test and are shown above each graph (∗∗∗P < .0001; ∗∗P < .001; ∗P < .05; NS, no significant difference). HMPR, Healthy mutation-positive relative. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 A, Correlation plots and curves of sFASL and vitamin B12, IL-10, and αβ-DNTs. B, Receiver operator characteristic curves for αβ-DNTs, sFASL, IL-10, and vitamin B12. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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