1. Fall of the Optical Wall: Freedom from the Tyranny of the Microscope Improves Glioma Risk Stratification 
Vijay Ramaswamy, Michael D. Taylor 
Cancer Cell 
Volume 29, Issue 2, Pages (February 2016)
DOI: /j.ccell
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Graphical Representation of the Current Morphological Classification and the Proposed Molecular Classification of Diffuse Glioma on the Left
Right: Currently, after surgery/biopsy (1), tumors are graded morphologically (2) and are risk-stratified to receive either conservative management usually omitting radiation or aggressive management based on the presumption that the morphology of the tumor represents its underlying biology (3). The prognostic value of this morphological classification, particularly in those of lower grades, is indeterminate and the subject of controversy (4). Left: The proposed molecular classification based on Ceccarelli et al. (2016), Brat et al. (2015), and Eckel-Passow et al. (2015) showing that after surgery/biopsy (1), molecular classification based on IDH status, 1p19q co-deletion, and methylation pattern (2) results in a robust risk stratification of either good prognosis or a poor-prognosis tumor to be considered as aggressive glioblastoma (3).
Cancer Cell  , DOI: ( /j.ccell )
Copyright © 2016 Elsevier Inc. Terms and Conditions