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Marcel J. Steggerda, Henk G. van der Poel, Luc M.F. Moonen 

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Presentation on theme: "Marcel J. Steggerda, Henk G. van der Poel, Luc M.F. Moonen "— Presentation transcript:

1 Predicting Urinary Morbidity after Brachytherapy of Localized Prostate Cancer 
Marcel J. Steggerda, Henk G. van der Poel, Luc M.F. Moonen  European Urology Supplements  Volume 7, Issue 12, Pages (November 2008) DOI: /j.eursup Copyright © 2008 European Association of Urology Terms and Conditions

2 Fig. 1 International Prostate Symptom Score (IPSS) as a function of postimplant time interval published by different authors [4,10,15,18,21]. * Indicates a study with mean IPSS values. ** Indicates a study with median IPSS values. Note: 0 mo represents the situation before treatment. European Urology Supplements 2008 7, DOI: ( /j.eursup ) Copyright © 2008 European Association of Urology Terms and Conditions

3 Fig. 2 Transversal ultrasound image through the midgland. (a) “Peripheral” loading of the seeds to spare the urethra; dose at the center of the urethra is 197Gy. (b) “Uniform” loading of the seeds; the needle at D3.5 is likely to puncture the urethra; dose at the center of the urethra is 330Gy. Legend: White line, prostate contour; orange line, 145Gy isodose; light green line, 290Gy isodose; blue line, 72.5Gy isodose; dark green line, urethra contour; orange dots, I-125 seed sources. European Urology Supplements 2008 7, DOI: ( /j.eursup ) Copyright © 2008 European Association of Urology Terms and Conditions

4 Fig. 3 Dose build-up implant with I-125 sources and Pd-103 sources. Because of the shorter half-value time of Pd-103 (17 d) compared with I-125 (60 d), the dose builds up much faster in prostates implanted with Pd-103; consequently, the radiation dose is expected to take effect earlier. Greater biologic effectiveness requires a lower total dose when applying Pd-103 (usually 125Gy) than when applying I-125 (usually 145Gy). European Urology Supplements 2008 7, DOI: ( /j.eursup ) Copyright © 2008 European Association of Urology Terms and Conditions


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