1. Autoreactive CD8 T Cells in Organ-Specific Autoimmunity
Roland S. Liblau, F.Susan Wong, Lennart T. Mars, Pere Santamaria 
Immunity 
Volume 17, Issue 1, Pages 1-6 (July 2002)
DOI: /S (02)

2. Figure 1
Activation, Differentiation, and Recruitment of Autoreactive CD8 T Cells as Targets for Therapeutic Intervention in Organ-Specific Autoimmunity
CD8 T cell-induced autoimmunity might be inhibited at the systemic level by depletion of APC types capable of crosspresenting target cell-derived peptides, by depletion of antigen-activated T-helper cells (explosives), or by potentiating the suppressor activity of regulatory T cells (ambulance). Strategies that might be effective at the regional level include costimulatory blockade, inhibition of CD8 T cells trafficking to the target tissue or of antigen-loaded APCs to the regional lymphoid tissue, inhibition of death effector pathways, and inhibition of apoptotic cell capture by local APCs (stop sign).
Immunity  , 1-6DOI: ( /S (02) )