1. Evaluating Effects of CFTR Modulation in Cystic Fibrosis

3. Cystic Fibrosis A Genetic Disease

4. Six Classes of CFTR Gene Mutations

5. CFTR Mutation Classification

6. Six Classes of CFTR Gene Mutations

7. Modulators, Potentiators, Correctors

8. Ivacaftor (Potentiator) in G551D Gating Mutation

9. Ivacaftor (Potentiator) Plus Lumacaftor (Corrector) in F508del CFTR TRAFFIC and TRANSPORT

10. Considerations for CFTR Modulator Therapy in Children Younger Than 12 y

11. Ivacaftor in Children Aged 6 to 11 y

12. Ivacaftor in Very Young Children (2 to 5 y) KIWI

13. Ivacaftor in Non-G551D Gating Mutations KONNECTION

14. Medical Management of CF

15. Use of Ivacaftor in Children

16. Use of Lumacaftor-Ivacaftor in Adults Baylor Experience – Patient Selection

17. Lumacaftor-Ivacaftor in Adults Baylor Experience

18. Abbreviations