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From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease

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Presentation on theme: "From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease"— Presentation transcript:

1 From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease
Peter T. McKenney, Eric G. Pamer  Cell  Volume 163, Issue 6, Pages (December 2015) DOI: /j.cell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Colonization Resistance
The gut microbiome contributes to colonization resistance through at least four inter-related functions. (1) Direct inhibition of neighboring bacteria via the production of toxic compounds. (2) Maintenance of the mucus barrier and underlying intestinal epithelium. (3) Regulation of the immune response. (4) Efficient utilization of host nutrients, such as mucus polysaccharides, by commensals may serve to limit the expansion of less well-adapted invading microbes. Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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