1. Insulin Therapy & Vascular Function : Logic for New Approaches to Diabetes Care: A Translational and Evidence-Based Practice Interpretation
Stan Schwartz MD, FACP, FACE
Affiliate Main Line Health
Emeritus, Clinical Assoc. Prof. Medicine
Univ of Pa.

2. In compliance with the accrediting board policies, the
Presenter Disclosure Information
In compliance with the accrediting board policies, the
American Diabetes Association requires the following
disclosure to the participants:
Stanley Schwartz
Research Support: 0
Employee: 0
Board Member/Advisory Panel: Janssen, Merck, AZ-BMS, BI-Lilly, Salix, Novo, Genesis Biotechnology Group
Stock/Shareholder: Saturn EMR Decision Support APP.
Consultant: NIH RO1 DK085212, Struan Grant PI
Other: Speaker’s Bureaus: Janssen, Merck, Novo, Salix, BI-LILLY, Eisai, AZ-Int’l, Amgen

3. Is Insulin Beneficial for the Vasculature (and the Patient) or NOT ??

4. Normal Physiology of Insulin re: The Vasculature; Counteracting Transient Oxidative Stress of Feeding
Dandona P, Aljada A, Mohanty P. Diabetologia Jun;45:

5. At Normal Insulin Concentrations: Benefits on Vasculature
Many Still use as argument for Early Insulin Therapy in Diabetes
BUT!!
Circulation. 2005;111: Metabolic Syndrome A Comprehensive Perspective Based on Interactions Between Obesity,
Diabetes, and Inflammation, Paresh Dandona

6. Even Dandona appreciated the Adverse Effects of Insulin
At Abnormal Insulin Concentrations- Hyperinsulinism : Adverse Effects on Vasculature
Even Dandona appreciated the Adverse Effects of Insulin
Circulation. 2005;111: Metabolic Syndrome A Comprehensive Perspective Based on Interactions Between Obesity,
Diabetes, and Inflammation,Paresh Dandona

7. Balance of Insulin Effects
Mechanisms of Disease: pathway-selective insulin resistance and microvascular complications of diabetes Per-Henrik Groop*,
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM DECEMBER 2005 VOL 1 NO 2