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Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study  Tatiana.

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Presentation on theme: "Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study  Tatiana."— Presentation transcript:

1 Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study  Tatiana Cristina Moraes Pinto Blumetti, MD, Marcela Pecora Cohen, PhD, Elimar Elias Gomes, MD, Mariana Petaccia de Macedo, PhD, Maria Dirlei Ferreira de Souza Begnami, PhD, José Humberto Tavares Guerreiro Fregnani, PhD, João Pedreira Duprat, PhD, Giovanni Pellacani, MD, Gisele Gargantini Rezze, PhD  Journal of the American Academy of Dermatology  Volume 73, Issue 2, Pages (August 2015) DOI: /j.jaad Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Optical coherence tomography (OCT) images, histopathology, and corresponding schematic images of the previously reported and new structures observed in the epidermis. A, Epidermis: junctional nevus with rete ridges pattern (finger-shaped appearance visualized within the dermoepidermal junction [DEJ]), histopathology (hematoxylin-eosin stain) corresponding to the OCT image. B, Melanoma in situ with absence of rete ridges pattern (not possible to visualize the papillae contour), histopathology (hematoxylin-eosin stain) of correspondent OCT image. Different aspects in rete ridges pattern: elongation (rete tips >2 times the epidermis thickness) (C) and enlargement (increase in size of epidermal tips >3 times the usual size) (D). E, Rectification (flattening of the epidermis followed by a hyporeflective area underneath). F, Fusion of rete pegs (fusion of epidermal tips characterized by circular or oval hyporeflective area at the DEJ). A-D and F are previously described features in the literature.3,5 Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Optical coherence tomography images and corresponding schematic images of the previously reported and new structures observed in the dermoepidermal junction (DEJ) and dermis. A, DEJ, melanoma in situ: loss of normal dermoepidermal index (inversion of normal reflective properties of the skin with epidermis hyporeflective/dermis hyperreflective). B, Junctional nevus: clear visualization of junctional nests (hyporeflective rounded areas well demarcated localized in the apical areas of rete ridges). C, Dermis, compound nevus: hyporeflective band (hyporeflective homogeneous band in dermis parallel to epidermis close to DEJ, preserving the hyperreflective collagen underneath). D, Invasive melanoma: icicle-shaped structures (hyperreflective large vertical icicle-shaped structures reaching the reticular dermis with their peak aspect). E and F, Melanoma in situ and invasive melanoma: shadows (focal areas with complete loss of visualization of dermis). Collagen (dermis with its normal hyperreflectivity bundles between linear hyporeflective structures) can be observed clearly (B and C). B and D are already described features in literature.3,5 Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions


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