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LRP1-deleted mice have a stunted phenotype and recapitulate pathophysiological aspects of stunting in humans. LRP1-deleted mice have a stunted phenotype.

Published byAudra Carpenter Modified over 5 years ago

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Presentation on theme: "LRP1-deleted mice have a stunted phenotype and recapitulate pathophysiological aspects of stunting in humans. LRP1-deleted mice have a stunted phenotype."— Presentation transcript:

1 LRP1-deleted mice have a stunted phenotype and recapitulate pathophysiological aspects of stunting in humans. LRP1-deleted mice have a stunted phenotype and recapitulate pathophysiological aspects of stunting in humans. (A) LRP1 RNA levels in whole blood from 1-y-old control (Con) or stunted (St) children. ENO3 was chosen as an unaffected control. (B) Percentage weight gain in LRP-1fl/flCre-ERt2+ (LRP1−) and LRP-1+/+Cre-ERt2+ (LRP1+) mice after injection of tamoxifen. ***P < (C) Appearance of LRP1+ and LRP1− littermates 40 d postinjection of tamoxifen. (D) Inguinal fat pad weight in LRP+ and LRP− mice. Each dot represents one animal. (E) Levels of Ly6Chi inflammatory macrophages in intestinal lamina propria from LRP1+ and LRP1− mice. (F) Serum FITC dextran levels in LRP1+ and LRP1− mice at 0 and 28 d posttamoxifen treatment. Robin Uchiyama et al. PNAS 2018;115:48:E11264-E11273 ©2018 by National Academy of Sciences

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