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Phosphorus Nutrition and the Treatment of Osteoporosis

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Presentation on theme: "Phosphorus Nutrition and the Treatment of Osteoporosis"— Presentation transcript:

1 Phosphorus Nutrition and the Treatment of Osteoporosis
Robert P. Heaney, MD  Mayo Clinic Proceedings  Volume 79, Issue 1, Pages (January 2004) DOI: / Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Figure 1 Portion of the elderly osteoporotic population most likely to be susceptible to insufficient phosphorus intake. Domain sizes are not drawn to scale. Mayo Clinic Proceedings  , 91-97DOI: ( / ) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

3 Figure 2 Total phosphorus intake and available phosphorus in individuals ingesting 70% of the recommended daily allowance for phosphorus under varying conditions of calcium supplementation. A, All supplemental calcium as carbonate or citrate. B, Same as for A, except for the addition of a single serving of milk to the diet. C, Same as for A, except that the calcium supplemental intake is in the form of tricalcium phosphate. Mayo Clinic Proceedings  , 91-97DOI: ( / ) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

4 Figure 3 Percentage of phosphorus absorption from single meals (±1 SEM) with and without ingestion of supplemental calcium, showing the relationship to time of supplement ingestion. The phosphorus content of the diet was 370 mg, and the calcium supplement dose was 1000 mg given as the acetate salt. Net phosphorus absorption averaged nearly 80% with no calcium supplement, 31% with simultaneous ingestion, and 59% when the calcium was delayed for 2 hours. Data from Schiller et al.17 Mayo Clinic Proceedings  , 91-97DOI: ( / ) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions

5 Figure 4 Fasting serum parathyroid hormone (PTH) and 24-hour urinary N-telopeptide (NTx) levels (±1 SEM) after 1 week of no supplementation (control), 1 week of CaCO3, and 1 week of Ca3(PO4)2. The 2 calcium preparations provided 1800 mg/d of calcium. The difference from control was statistically significant (P<.01) in each case, whereas there was no difference between the 2 calcium sources for either end point. Mayo Clinic Proceedings  , 91-97DOI: ( / ) Copyright © 2004 Mayo Foundation for Medical Education and Research Terms and Conditions


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