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Progressive multifocal leukoencephalopathy: an unexpected complication of modern therapeutic monoclonal antibody therapies  E. Tavazzi, P. Ferrante, K.

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Presentation on theme: "Progressive multifocal leukoencephalopathy: an unexpected complication of modern therapeutic monoclonal antibody therapies  E. Tavazzi, P. Ferrante, K."— Presentation transcript:

1 Progressive multifocal leukoencephalopathy: an unexpected complication of modern therapeutic monoclonal antibody therapies  E. Tavazzi, P. Ferrante, K. Khalili  Clinical Microbiology and Infection  Volume 17, Issue 12, Pages (December 2011) DOI: /j x Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 JC virus circular DNA encodes for early transcripts, including small and large T antigen and for late proteins (capsid proteins VP1, VP2, VP3 and agnoprotein). Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Axial FLAIR sequence of the brain showing hyperintense, multifocal, bilateral asymmetrical lesions of the white matter, mainly involving the posterior regions (reproduced with the courtesy of Prof. S. Bastianello). Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions


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