1. Structural and Microstructural Brain Changes Predict Impairment in Daily Functioning 
Vincentius J.A. Verlinden, MSc, Jos N. van der Geest, PhD, Marius de Groot, MSc, Albert Hofman, MD, PhD, Wiro J. Niessen, PhD, Aad van der Lugt, MD, PhD, Meike W. Vernooij, MD, PhD, M. Arfan Ikram, MD, PhD 
The American Journal of Medicine 
Volume 127, Issue 11, Pages e2 (November 2014)
DOI: /j.amjmed
Copyright © 2014 Elsevier Inc. Terms and Conditions

2. Figure
Structural and microstructural brain changes on magnetic resonance imaging. Left on the image corresponds to right in the brain. (A) Lacunar infarct (arrow) on T1-weighted image. (B) White matter lesions (arrow) on fluid attenuation inversion recovery (FLAIR) image. (C) Cerebral microbleed (arrow) on T2*-weighted image. (D) Tissue segmentation with each tissue type represented in a different gray value (darkest gray = cerebrospinal fluid, gray = gray matter, light gray = normal-appearing white matter, white = white matter lesion). (E) Diffusion tensor imaging (DTI) map of fractional anisotropy with larger values indicating larger anisotropy. (F) DTI map of mean diffusivity with larger values indicating larger diffusivity.
The American Journal of Medicine  , e2DOI: ( /j.amjmed )
Copyright © 2014 Elsevier Inc. Terms and Conditions