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Heterogeneity in Definitions of Endpoints for Clinical Trials of Ulcerative Colitis: A Systematic Review for Development of a Core Outcome Set  Christopher.

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Presentation on theme: "Heterogeneity in Definitions of Endpoints for Clinical Trials of Ulcerative Colitis: A Systematic Review for Development of a Core Outcome Set  Christopher."— Presentation transcript:

1 Heterogeneity in Definitions of Endpoints for Clinical Trials of Ulcerative Colitis: A Systematic Review for Development of a Core Outcome Set  Christopher Ma, Remo Panaccione, Richard N. Fedorak, Claire E. Parker, Tran M. Nguyen, Reena Khanna, Corey A. Siegel, Laurent Peyrin-Biroulet, Geert D’Haens, William J. Sandborn, Brian G. Feagan, Vipul Jairath  Clinical Gastroenterology and Hepatology  Volume 16, Issue 5, Pages e13 (May 2018) DOI: /j.cgh Copyright © 2018 AGA Institute Terms and Conditions

2 Figure 1 Flow diagram for assessment of trials identified by the search strategy. RCT, randomized controlled trial; UCDAI, Ulcerative Colitis Disease Activity Index. Clinical Gastroenterology and Hepatology  , e13DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

3 Figure 2 Proportion of placebo-controlled ulcerative colitis trials reporting key efficacy and safety outcome domains, stratified by decade of publication. Clinical Gastroenterology and Hepatology  , e13DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions

4 Figure 3 Outcome reporting matrix for placebo-controlled ulcerative colitis trials. Clinical Gastroenterology and Hepatology  , e13DOI: ( /j.cgh ) Copyright © 2018 AGA Institute Terms and Conditions


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