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Defining an extended-spectrum β-lactamase

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Presentation on theme: "Defining an extended-spectrum β-lactamase"— Presentation transcript:

1 Defining an extended-spectrum β-lactamase
D.M. Livermore  Clinical Microbiology and Infection  Volume 14, Pages 3-10 (January 2008) DOI: /j x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

2 Fig. 1 Structure of an oxyimino-aminothiazolyl cephalosporin. The C=N–OR group, shaded, is held rigid and shields the β-lactam ring from attack by classic β-lactamases, but not by extended-spectrum β-lactamases. Cefuroxime, cefotaxime, ceftriaxone, ceftazidime, cefepime and cefpirome are all designed on this scaffold. Clinical Microbiology and Infection  , 3-10DOI: ( /j x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions


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